NEFL and MTMR2

Number of citations of the paper that reports this interaction (PMID 12837694)
11

Data Source:
HPRD (in vivo, two hybrid)

		NEFL	MTMR2
Gene Name		neurofilament, light polypeptide	myotubularin related protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Neurofilament Axon Growth Cone TSC1-TSC2 Complex	Nucleus Cytoplasm Vacuolar Membrane Cytosol Synaptic Vesicle Axon Dendrite Early Endosome Membrane Dendritic Spine Extracellular Vesicular Exosome Synaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Phospholipase Binding	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Homodimerization Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Microtubule Cytoskeleton Organization Synaptic Transmission Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axon Transport Of Mitochondrion Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Intermediate Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone	Negative Regulation Of Receptor Internalization Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Peptidyl-tyrosine Dephosphorylation Small Molecule Metabolic Process Negative Regulation Of Endocytosis Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Neuron Development Protein Tetramerization Negative Regulation Of Excitatory Postsynaptic Membrane Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process
Pathways		Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Synthesis of PIPs at the early endosome membrane Metabolism of lipids and lipoproteins Phospholipid metabolism Synthesis of PIPs at the late endosome membrane PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: BRD7 CCNC CDK5RAP2 CHD3 ENKD1 GRIN1 KDM1A KIFC3 KRT15 MAP2 MTMR2 MYO5A NDN NEFH NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 SPTAN1 TERF1 TEX11 TSC1 TXLNB USP2 VIM YWHAG	3 interactors: NEFL SBF1 SNTA1
Entrez ID		4747	8898
HPRD ID		01206	04650
Ensembl ID			ENSG00000087053
Uniprot IDs		P07196	Q13614
PDB IDs			1LW3 1M7R 1ZSQ 1ZVR
Enriched GO Terms of Interacting Partners?		Nervous System Development Developmental Process Anatomical Structure Development Regulation Of Cellular Component Organization System Development Central Nervous System Development Organelle Organization Cell Differentiation Cell Projection Organization Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Neurogenesis Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Cell Cycle Cell Development Movement Of Cell Or Subcellular Component Microtubule-based Process Intermediate Filament Organization Axonogenesis Regulation Of Cellular Process Response To Stimulus G2/M Transition Of Mitotic Cell Cycle Axon Development Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Cycle Cellular Component Maintenance Chromatin Modification Negative Regulation Of Biosynthetic Process Neuron Development Regulation Of Transcription From RNA Polymerase II Promoter Neuron Projection Morphogenesis Myelination Axon Ensheathment Chromosome Organization Cell Cycle Process Regulation Of Gene Expression Regulation Of Microtubule-based Process Chromatin Organization Cell Morphogenesis Involved In Differentiation Intermediate Filament Cytoskeleton Organization Neuron Differentiation Intermediate Filament-based Process Protein Oligomerization Microtubule Bundle Formation Microtubule Cytoskeleton Organization Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis	Regulation Of Vasoconstriction By Circulating Norepinephrine Neurofilament Bundle Assembly Negative Regulation Of Peptidyl-cysteine S-nitrosylation Intermediate Filament Bundle Assembly Axon Transport Of Mitochondrion Regulation Of Axon Diameter Regulation Of Cell Projection Size Retrograde Axon Cargo Transport Peripheral Nervous System Axon Regeneration Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Neurofilament Cytoskeleton Organization Intermediate Filament Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Anterograde Axon Cargo Transport Cardiac Muscle Cell Action Potential Involved In Contraction Response To Corticosterone Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Response To Mineralocorticoid Intermediate Filament Cytoskeleton Organization Axon Regeneration Intermediate Filament-based Process Regulation Of Cardiac Muscle Cell Contraction Neuron Projection Regeneration Axon Cargo Transport Neuromuscular Junction Development Regulation Of Vasoconstriction
Tagcloud ?		abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Difference) ?		abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Intersection) ?