NEFL and MYO15B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NEFL	MYO15B
Description		neurofilament light chain	myosin XVB
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Neurofilament Axon Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Intermediate Filament Cytoskeleton Schaffer Collateral - CA1 Synapse Cholinergic Synapse Postsynaptic Intermediate Filament Cytoskeleton Presynaptic Intermediate Filament Cytoskeleton Axon Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Tubulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Anterograde Axonal Transport Retrograde Axonal Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axonal Transport Of Mitochondrion Spinal Cord Development Hippocampus Development Cerebral Cortex Development Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Intermediate Filament Polymerization Or Depolymerization Intermediate Filament Organization Intermediate Filament Bundle Assembly Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone Neurofilament Cytoskeleton Organization Regulation Of Synapse Maturation Motor Neuron Apoptotic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Response To Sodium Arsenite Response To Acrylamide Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Fear of minor pain ( 28701861) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		55 interacting genes: BRD7 CCDC13 CCDC172 CCDC33 CCNC CDK5RAP2 CEP57L1 CHD3 DES DSCAM ENKD1 FXR1 GFAP GOLGA2 GORASP1 GRIN1 HGS ITSN1 KDM1A KIFC3 KLC3 KRT13 KRT15 KRT18 MAP2 MTMR2 MTUS2 MYO15B MYO5A NDN NEFH NEIL3 NEK6 NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 RBM11 SHANK3 SKIL SMYD1 SPTAN1 TERF1 TEX11 TRIM55 TRIM63 TSC1 TXLNB USHBP1 USP2 VIM YWHAG	96 interacting genes: ABI2 ADAMTSL4 BEND7 C7orf57 CARD9 CCNC CEP57L1 CFAP68 COIL CRX DNAJA3 DUSP21 ERAS FAM9B FHL2 GAB2 GADD45GIP1 GFAP GINS3 GPRASP3 HOXA1 IHO1 IKZF3 KATNBL1 KCNJ6 KIAA0408 KIF24 KIFC3 KLF4 KLHL12 KRT13 KRT31 KRT34 KRT35 KRT75 LIMS1 MTUS2 MYOZ3 NADSYN1 NBPF19 NDUFA12 NECAB2 NEDD4 NEFL NHSL2 NKAPD1 NOTCH2NLA NR1D2 NUP62 PAK5 PKNOX2 PLEKHA3 PNMA1 PNMA5 POU6F2 PPM1K PRKAR1B RAD54B RBM11 RCN1 RCN3 REL RPH3AL RUNDC3A SAXO4 SLA SORBS3 SPATC1L SPRED2 SSBP4 TCF12 TCF4 TEX13A TFIP11 TLE5 TPRN TRAF2 TRIM14 TRIM27 TRIM29 TRIM54 TSC22D4 UBQLN2 VGLL3 ZBED1 ZBTB10 ZBTB3 ZBTB32 ZBTB8A ZCCHC14 ZMAT1 ZNF114 ZNF438 ZNF774 ZNF837 ZNRD2
Entrez ID		4747	80022
HPRD ID		01206
Ensembl ID		ENSG00000277586	ENSG00000266714
Uniprot IDs		P07196	Q96JP2 Q9H614
PDB IDs			2DLP
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Microtubule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Cytoplasm Intermediate Filament Organization Organelle Organization Centrosome Structural Constituent Of Cytoskeleton Intermediate Filament Cell Projection Microtubule-based Process Regulation Of Nervous System Development Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Neuron Projection Centrosome Cycle Intermediate Filament Cytoskeleton Regulation Of Neurogenesis Supramolecular Fiber Organization Regulation Of Developmental Process Regulation Of Microtubule Polymerization Regulation Of Neuron Projection Development Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Plasma Membrane Bounded Cell Projection Organization Scaffold Protein Binding Dendritic Spine Cell Projection Organization Microtubule Organizing Center Organization Gamma-tubulin Binding Protein Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Nervous System Development Regulation Of Cell Development Regulation Of Cell Projection Organization Microtubule Organizing Center Regulation Of Cell Differentiation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Organelle Organization Regulation Of Organelle Transport Along Microtubule Kinesin Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein-containing Complex Assembly Organelle Assembly Calmodulin Binding	Identical Protein Binding Intermediate Filament Organization Protein Binding Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Supramolecular Fiber Organization Structural Constituent Of Skin Epidermis Intermediate Filament Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of RNA Metabolic Process Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Keratin Filament DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding
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