PKLR

Gene Name		pyruvate kinase, liver and RBC
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Pyruvate Kinase Activity ATP Binding Potassium Ion Binding
	Biological Process	Response To Hypoxia Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Energy Reserve Metabolic Process ATP Biosynthetic Process Response To Nutrient Pathogenesis Response To Heat Response To Glucose Response To Lithium Ion Phosphorylation Endocrine Pancreas Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Insulin Stimulus Response To ATP Pyruvate Biosynthetic Process Small Molecule Metabolic Process Response To CAMP Response To Other Organism
Pathways
Drugs		Pyruvic acid 2-Phosphoglycolic Acid Fructose-1,6-Diphosphate
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Urate levels ( 23263486)
Protein-protein Interactions		3 interactors: CLEC4G MYOC PCNA
Entrez ID		5313
HPRD ID		11841
Ensembl ID		ENSG00000143627
Uniprot IDs		P30613
PDB IDs		2VGB 2VGF 2VGG 2VGI 4IMA 4IP7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deoxyribonuclease Activity Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway ERBB2 Signaling Pathway Leading Strand Elongation Non-canonical Wnt Signaling Pathway Via JNK Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Translesion Synthesis Neuronal Ion Channel Clustering Negative Regulation Of Actin Filament Bundle Assembly Nucleotide-excision Repair, DNA Gap Filling Regulation Of Mitochondrial Depolarization Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nuclear DNA Replication Telomere Maintenance Via Recombination Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Hypertrophy Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Neuron Maturation DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Membrane Depolarization Negative Regulation Of Cell-matrix Adhesion Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Stress Fiber Assembly Myelination In Peripheral Nervous System Regulation Of Focal Adhesion Assembly Positive Regulation Of Actin Filament Bundle Assembly Schwann Cell Development Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Nuclease Activity Response To Cadmium Ion Regulation Of Cell Junction Assembly Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Mismatch Repair Base-excision Repair
Tagcloud ?		adaptation ago altitude ancestry asian challenged coordinated cyp2e1 deedu du edar environments epas1 extreme han highlanders insight migrated mongolian mongolians neighboring plateau pparg qinghai steppes tianjiao1 tibetan tibetans trait