PKLR and CPNE7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PKLR	CPNE7
Description		pyruvate kinase L/R	copine 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Pyruvate Kinase Complex	Nucleus Cytoplasm Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Ion Binding Metal Ion Binding Monosaccharide Binding	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Glycolytic Process Response To Nutrient Response To Glucose Response To Metal Ion Cellular Response To Insulin Stimulus Response To ATP Pyruvate Biosynthetic Process Response To CAMP Cellular Response To Epinephrine Stimulus	Lipid Metabolic Process Cellular Response To Calcium Ion
Pathways			Glycerophospholipid biosynthesis
Drugs		Pyruvic acid 2-Phosphoglycolic Acid beta-D-fructofuranose 1,6-bisphosphate Mitapivat
Diseases		Pyruvate kinase (PK) deficiency, including: Red cell pyruvate kinase (PK) deficiency; Pyruvate kinase hyperactivity
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 24777453) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Major depressive disorder ( 29317602) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 23263486)	Age at first sexual intercourse ( 27089180) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Smoking behaviour (cigarette pack-years) ( 30679032)
Interacting Genes		6 interacting genes: CLEC4G CPNE7 FNDC3B MYOC PCNA PTBP1	28 interacting genes: ADAMTSL4 CALCOCO2 CSNK2B DDIT4L DUSP21 EFHC2 GPX7 KRT75 LHX3 MEOX2 NECAB1 OTP PBX4 PICK1 PKLR REL SAXO1 TEPSIN TRIM23 TRIM27 ZFP90 ZMIZ2 ZNF18 ZNF474 ZNF572 ZNF655 ZNF774 ZRANB1
Entrez ID		5313	27132
HPRD ID		11841	05749
Ensembl ID		ENSG00000143627	ENSG00000178773
Uniprot IDs		P30613	Q9UBL6
PDB IDs		2VGB 2VGF 2VGG 2VGI 4IMA 4IP7 5SC8 5SC9 5SCA 5SCB 5SCC 5SCD 5SCE 5SCF 5SCG 5SCH 5SCI 5SCJ 5SCK 5SCL 5SDT 6NN4 6NN5 6NN7 6NN8 7FRV 7FRW 7FRX 7FRY 7FRZ 7FS0 7FS1 7FS2 7FS3 7FS4 7FS5 7FS6 7FS7 7FS8 7FS9 7FSA 7FSB 7FSC 7FSD 7QDN 7QZU 8TBS 8TBT 8TBU 8XFD
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Negative Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Skeletal Muscle Hypertrophy PCNA Complex Replisome Virus Coreceptor Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Poly-pyrimidine Tract Binding Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Glycosylated Region Protein Binding	Metal Ion Binding Zinc Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II
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