PKLR and CLEC4G

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		PKLR	CLEC4G
Gene Name		pyruvate kinase, liver and RBC	C-type lectin domain family 4, member G
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Pyruvate Kinase Activity ATP Binding Potassium Ion Binding	Protein Binding Carbohydrate Binding
	Biological Process	Response To Hypoxia Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Energy Reserve Metabolic Process ATP Biosynthetic Process Response To Nutrient Pathogenesis Response To Heat Response To Glucose Response To Lithium Ion Phosphorylation Endocrine Pancreas Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Insulin Stimulus Response To ATP Pyruvate Biosynthetic Process Small Molecule Metabolic Process Response To CAMP Response To Other Organism
Pathways
Drugs		Pyruvic acid 2-Phosphoglycolic Acid Fructose-1,6-Diphosphate
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Urate levels ( 23263486)
Protein-Protein Interactions		3 interactors: CLEC4G MYOC PCNA	19 interactors: APOA1 APOH ARSA ASGR1 AZU1 CAPN1 COX1 CPN1 EIF6 FTL GEM IFI35 MAP3K11 NUP214 PKLR PRDX1 RPSA SHBG WBP2
Entrez ID		5313	339390
HPRD ID		11841	16721
Ensembl ID		ENSG00000143627	ENSG00000182566
Uniprot IDs		P30613	B7ZKQ2 Q08G24 Q6UXB4 Q6XYD1
PDB IDs		2VGB 2VGF 2VGG 2VGI 4IMA 4IP7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deoxyribonuclease Activity Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway ERBB2 Signaling Pathway Leading Strand Elongation Non-canonical Wnt Signaling Pathway Via JNK Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Translesion Synthesis Neuronal Ion Channel Clustering Negative Regulation Of Actin Filament Bundle Assembly Nucleotide-excision Repair, DNA Gap Filling Regulation Of Mitochondrial Depolarization Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nuclear DNA Replication Telomere Maintenance Via Recombination Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Hypertrophy Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Neuron Maturation DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Membrane Depolarization Negative Regulation Of Cell-matrix Adhesion Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Stress Fiber Assembly Myelination In Peripheral Nervous System Regulation Of Focal Adhesion Assembly Positive Regulation Of Actin Filament Bundle Assembly Schwann Cell Development Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Nuclease Activity Response To Cadmium Ion Regulation Of Cell Junction Assembly Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Mismatch Repair Base-excision Repair	Positive Regulation Of Lipoprotein Lipase Activity Nuclear Export Ribosome Assembly Response To Extracellular Stimulus Response To Steroid Hormone Response To Organic Cyclic Compound Response To Stimulus Response To Estrogen Response To Nutrient Response To Hormone Regulation Of Interleukin-1 Beta Production Positive Regulation Of Fractalkine Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Biosynthetic Process Negative Regulation Of Cell Adhesion Molecule Production Primary Spermatocyte Growth Nucleocytoplasmic Transport Nuclear Transport RNA Export From Nucleus RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Negative Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Histone H3-K14 Acetylation Cellular Localization Catabolic Process Response To Organic Substance Positive Regulation Of Lipase Activity Viral Transcription Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Regulation Of Histone H3-K14 Acetylation Triglyceride Transport Receptor-mediated Endocytosis Lipid Metabolic Process Response To Stress Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Negative Regulation Of Interleukin-1 Secretion Establishment Of Localization In Cell Cellular Process Response To Lipid Bradykinin Catabolic Process RRNA Transport Pyruvate Biosynthetic Process Membrane Organization Response To Nutrient Levels Mature Ribosome Assembly RRNA 3'-end Processing High-density Lipoprotein Particle Clearance Cellular Response To Stimulus RNA Transport Protein Oxidation
Tagcloud ?		adaptation ago altitude ancestry asian challenged coordinated cyp2e1 deedu du edar environments epas1 extreme han highlanders insight migrated mongolian mongolians neighboring plateau pparg qinghai steppes tianjiao1 tibetan tibetans trait
Tagcloud (Difference) ?		adaptation ago altitude ancestry asian challenged coordinated cyp2e1 deedu du edar environments epas1 extreme han highlanders insight migrated mongolian mongolians neighboring plateau pparg qinghai steppes tianjiao1 tibetan tibetans trait
Tagcloud (Intersection) ?