CD163 and FCGR1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD163	FCGR1A
Description		CD163 molecule	Fc gamma receptor Ia
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Scavenger Receptor Activity Protein Binding Scaffold Protein Binding	Protein Binding IgG Receptor Activity High-affinity IgG Receptor Activity IgG Binding
	Biological Process	Acute-phase Response Inflammatory Response Vesicle-mediated Transport	Antibody-dependent Cellular Cytotoxicity Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Immune System Process Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Innate Immune Response Positive Regulation Of Phagocytosis Regulation Of Immune Response
Pathways		Scavenging of heme from plasma CD163 mediating an anti-inflammatory response	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs		Tetrachlorodecaoxide	Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS		Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 29083408)
Interacting Genes		6 interacting genes: CSNK2B FCGR1A HOXA1 HP MYH9 PRKCA	31 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CLIC6 CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B
Entrez ID		9332	2209
HPRD ID		05708	00904
Ensembl ID		ENSG00000177575	ENSG00000150337
Uniprot IDs		C9JHR8 Q86VB7	P12314
PDB IDs		8XMK 8XMP 8XMQ 8XMW 9FHB 9FMU 9FNO	3RJD 4W4O 4X4M 4ZNE 8DIN 8DIR 8DJ7
Enriched GO Terms of Interacting Partners?		Phosphorylation Protein Kinase CK2 Complex Protein Phosphorylation Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Phagocytosis, Engulfment Membrane Invagination High-affinity IgG Receptor Activity Acute Inflammatory Response Positive Regulation Of Type III Hypersensitivity Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Hydrogen Peroxide Catabolic Process Uropod Organization Myosin II Filament Cortical Granule Exocytosis Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex I-kappaB Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Type IIa Hypersensitivity Integrin Binding Actomyosin Contractile Ring Protein Kinase C Signaling Membrane Organization Release From Viral Latency Hemoglobin Binding Response To Reactive Oxygen Species Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Angiotensin-activated Signaling Pathway Protein Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle IgG Receptor Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Adiponectin-activated Signaling Pathway Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antibody-dependent Cellular Cytotoxicity Anatomical Structure Formation Involved In Morphogenesis	Immune System Process Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response Inflammatory Response Immune Effector Process Regulation Of Immune Response Leukocyte Degranulation Regulation Of Immune System Process Positive Regulation Of Monocyte Chemotactic Protein-1 Production Fc Receptor Signaling Pathway Immune Response Acute Inflammatory Response Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Positive Regulation Of Immune System Process Response To External Biotic Stimulus Regulation Of Cell Population Proliferation Regulation Of Interleukin-8 Production Regulation Of Superoxide Metabolic Process Cellular Response To Molecule Of Fungal Origin Membrane Extracellular Region Fc-gamma Receptor Signaling Pathway Exocytosis Response To Molecule Of Fungal Origin Regulation Of Phagocytosis Regulated Exocytosis Plasma Membrane Acute-phase Response Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Complement Component C1q Complex Binding Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Neutrophil Differentiation Response To Other Organism Positive Regulation Of Myeloid Cell Apoptotic Process Defense Response To Fungus Cell Activation Virion Binding Positive Regulation Of Immune Response Response To Fungus Positive Regulation Of Interleukin-8 Production Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Negative Regulation Of Inflammatory Response Defense Response To Symbiont
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?