CD163 and HP

Number of citations of the paper that reports this interaction (PMID 11854028)
26

Data Source:
HPRD (in vivo)

		CD163	HP
Gene Name		CD163 molecule	haptoglobin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Membrane	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Scavenger Receptor Activity Protein Binding	Catalytic Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Receptor-mediated Endocytosis Acute-phase Response	Immune System Process Receptor-mediated Endocytosis Defense Response Acute-phase Response Metabolic Process Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Negative Regulation Of Oxidoreductase Activity Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways		Scavenging of heme from plasma	Scavenging of heme from plasma
Drugs
Diseases
GWAS		Hematological and biochemical traits ( 20139978)	Cholesterol, total ( 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 20686565) Metabolite levels ( 22916037)
Protein-Protein Interactions		4 interactors: CSNK2B HP MYH9 PRKCA	20 interactors: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		9332	3240
HPRD ID		05708	00772
Ensembl ID		ENSG00000177575	ENSG00000257017
Uniprot IDs		C9JHR8 Q86VB7	P00738 Q6PEJ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Vessel Endothelial Cell Migration Response To External Stimulus Chemotaxis Regulation Of Endothelial Cell Migration Negative Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Epithelial Cell Migration Histone H3-T6 Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Platelet Activation Leukocyte Migration Locomotion Negative Regulation Of Hydrogen Peroxide Metabolic Process Cell Cycle Uropod Organization Establishment Of Meiotic Spindle Localization Establishment Of T Cell Polarity Movement Of Cell Or Subcellular Component Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Angiogenesis Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Axon Guidance Regulation Of Hydrogen Peroxide Metabolic Process Endothelial Tube Morphogenesis Negative Regulation Of Glucose Import Blood Coagulation Blood Vessel Morphogenesis Hemostasis Positive Regulation Of Macrophage Differentiation Meiotic Spindle Organization Desmosome Organization Blood Vessel Development Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Immune System Process Axonogenesis Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Vasculature Development Protein Metabolic Process Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Axon Development	Regulation Of Body Fluid Levels Response To Stress Wound Healing Multicellular Organismal Development Response To Wounding Blood Coagulation Hemostasis Response To Stimulus Tissue Development Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Immune Response Defense Response Developmental Process Positive Regulation Of Cell Death Anatomical Structure Development Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Immune Response System Development Endocytosis Cellular Extravasation Activated T Cell Proliferation Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Reactive Oxygen Species Metabolic Process Cell Adhesion Organ Development Protein Oligomerization Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cytoskeleton Organization Gland Development Neutrophil Chemotaxis Positive Regulation Of Immune System Process Morphogenesis Of An Epithelium Neutrophil Migration Leukocyte Migration Single Organismal Cell-cell Adhesion Positive Regulation Of Transforming Growth Factor Beta3 Production Epidermal Cell Division Ectoderm And Mesoderm Interaction Granulocyte Chemotaxis Regulation Of Nitric Oxide Biosynthetic Process
Tagcloud ?		27cm3 39cm3 alternatively capacities ccl22 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous	antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4
Tagcloud (Difference) ?		27cm3 39cm3 alternatively capacities ccl22 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous	antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4
Tagcloud (Intersection) ?