CD163 and HP

Number of citations of the paper that reports this interaction (PubMedID 11854028)
0

Data Source:
HPRD (in vivo)

		CD163	HP
Description		CD163 molecule	haptoglobin
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen
	Molecular Function	Scavenger Receptor Activity Protein Binding Scaffold Protein Binding	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Acute-phase Response Inflammatory Response Vesicle-mediated Transport	Immune System Process Defense Response Acute-phase Response Inflammatory Response Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways		Scavenging of heme from plasma CD163 mediating an anti-inflammatory response	Scavenging of heme from plasma Neutrophil degranulation
Drugs		Tetrachlorodecaoxide	Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 29083408)	Cholesterol, total ( 20686565 25961943) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol ( 20686565 25961943) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010 33339817) Urinary haptoglobin levels in type 2 diabetes ( 29572449)
Interacting Genes		6 interacting genes: CSNK2B FCGR1A HOXA1 HP MYH9 PRKCA	21 interacting genes: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB HSP90AA1 ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		9332	3240
HPRD ID		05708	00772
Ensembl ID		ENSG00000177575	ENSG00000257017
Uniprot IDs		C9JHR8 Q86VB7	A0A0C4DGL8 P00738 Q6PEJ8
PDB IDs		8XMK 8XMP 8XMQ 8XMW 9FHB 9FMU 9FNO	4WJG 4X0L 5HU6 6TB2 8XMP 8XMQ 8XMW 9FHB 9FMU
Enriched GO Terms of Interacting Partners?		Phosphorylation Protein Kinase CK2 Complex Protein Phosphorylation Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Phagocytosis, Engulfment Membrane Invagination High-affinity IgG Receptor Activity Acute Inflammatory Response Positive Regulation Of Type III Hypersensitivity Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Hydrogen Peroxide Catabolic Process Uropod Organization Myosin II Filament Cortical Granule Exocytosis Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex I-kappaB Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Type IIa Hypersensitivity Integrin Binding Actomyosin Contractile Ring Protein Kinase C Signaling Membrane Organization Release From Viral Latency Hemoglobin Binding Response To Reactive Oxygen Species Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Angiotensin-activated Signaling Pathway Protein Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle IgG Receptor Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Adiponectin-activated Signaling Pathway Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antibody-dependent Cellular Cytotoxicity Anatomical Structure Formation Involved In Morphogenesis	Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Integrin AlphaM-beta2 Complex Protein Phosphatase Binding Positive Regulation Of Neutrophil Degranulation Extracellular Exosome Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neutrophil Degranulation Positive Regulation Of Reactive Oxygen Species Metabolic Process Complement Component C3b Binding Regulation Of Immune Response Protein Kinase Binding Protein Stabilization Protein Metabolic Process Endocytic Vesicle Lumen Response To Other Organism Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Response To Stress Ficolin-1-rich Granule Lumen Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Leukocyte Activation Integrin Complex Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Microglial Cell Activation Regulation Of Superoxide Metabolic Process Phagocytosis, Engulfment Response To External Biotic Stimulus Regulation Of Protein Targeting To Membrane Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Defense Response Endodermal Cell Differentiation Receptor-mediated Endocytosis Response To Cocaine
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