MYH10 and GPS2

		MYH10	GPS2
Description		myosin heavy chain 10	G protein pathway suppressor 2
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Spindle Cytosol Plasma Membrane Brush Border Cell Cortex Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Myosin Complex Myosin II Complex Sarcoplasm Lamellipodium Axon Growth Cone Midbody Neuromuscular Junction Cleavage Furrow Myosin Filament Actomyosin Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Myosin II Filament Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Supramolecular Fiber	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Transcription Repressor Complex
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding RNA Stem-loop Binding ADP Binding MRNA 5'-UTR Binding Actin Filament Binding	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding
	Biological Process	Mitotic Cytokinesis In Utero Embryonic Development Neuron Migration Plasma Membrane Repair Cardiac Septum Development Exocytosis Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Cell Adhesion Axonogenesis Axon Guidance Brain Development Heart Development Adult Heart Development Regulation Of Cell Shape Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Cerebellar Purkinje Cell Layer Development Actin Cytoskeleton Organization Actin Filament-based Movement Myofibril Assembly Actomyosin Structure Organization Neuron Projection Development Aorta Development Symbiont Entry Into Host Cell Positive Regulation Of Protein Secretion Neuromuscular Process Controlling Balance Cardiac Myofibril Assembly Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Retina Development In Camera-type Eye Coronary Vasculature Development Postsynaptic Actin Cytoskeleton Organization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Type 2 diabetes ( 30130595)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		14 interacting genes: ANXA1 APC BCAP31 DUX4 ECPAS FXR1 FXR2 MYH9 PBX1 PTEN S100A4 YWHAE YWHAG ZNF512B	53 interacting genes: ACTMAP AKAP8L ATF4 ATF5 BAG4 BRME1 CCNA1 CHD3 CNOT2 CYSRT1 DAZAP2 EP300 FAM168B FHL5 GOLGA2 HDAC1 HDAC3 HNRNPH1 HOXA1 INTS11 KRT27 KRT31 KRT34 KRT36 KRTAP11-1 KRTAP13-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 MAP3K7CL NCOR1 NDOR1 NR0B2 OIP5 PBK POU2AF1 PRMT6 PRR22 RBPMS SESTD1 SETDB1 SMUG1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53 TP53BP2 TRIP6 UBTD2 VPS37C
Entrez ID		4628	2874
HPRD ID		01178	11878
Ensembl ID		ENSG00000133026	ENSG00000132522
Uniprot IDs		A0A8I5KZ38 G1UI33 P35580	Q13227
PDB IDs		4PD3	2L5G
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Protein Targeting Dentate Gyrus Development Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Primary Metabolic Process Lateral Plasma Membrane Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Cytoplasmic Stress Granule Protein Localization To Endoplasmic Reticulum Cytoplasm Translation Regulator Activity Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Meiotic Spindle Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Plasma Membrane Bounded Cell Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mononuclear Cell Differentiation Regulation Of Wound Healing Regulation Of Mitotic Cell Cycle Phase Transition Molecular Function Inhibitor Activity Negative Regulation Of Metabolic Process Cytoplasmic Translational Initiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microfilament Motor Activity Positive Regulation Of Translation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Intermediate Filament Keratin Filament Circadian Rhythm Transcription Repressor Complex Structural Molecule Activity Histone Deacetylase Complex Rhythmic Process Transcription Cis-regulatory Region Binding P53 Binding NF-kappaB Binding Transcription Corepressor Binding Protein Binding Protein Lysine Delactylase Activity Cytosol Structural Constituent Of Skin Epidermis Circadian Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Transcription Corepressor Activity Histone Deacetylase Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Tissue Development Promoter-specific Chromatin Binding Mitotic Spindle Intermediate Filament Organization Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Androgen Receptor Signaling Pathway Cellular Response To UV Organelle Organization Negative Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression DNA-binding Transcription Factor Binding Chromatin Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?