MYH10 and ITGAE

Data Source: HiPPIP (Novel)

		MYH10	ITGAE
Name		myosin heavy chain 10	integrin subunit alpha E
Structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Spindle Cytosol Plasma Membrane Brush Border Cell Cortex Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Myosin Complex Myosin II Complex Sarcoplasm Lamellipodium Axon Growth Cone Midbody Neuromuscular Junction Cleavage Furrow Myosin Filament Actomyosin Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Myosin II Filament Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Supramolecular Fiber	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding RNA Stem-loop Binding ADP Binding MRNA 5'-UTR Binding Actin Filament Binding	Signaling Receptor Activity Metal Ion Binding
	Biological Process	Mitotic Cytokinesis In Utero Embryonic Development Neuron Migration Plasma Membrane Repair Cardiac Septum Development Exocytosis Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Cell Adhesion Axonogenesis Axon Guidance Brain Development Heart Development Adult Heart Development Regulation Of Cell Shape Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Cerebellar Purkinje Cell Layer Development Actin Cytoskeleton Organization Actin Filament-based Movement Myofibril Assembly Actomyosin Structure Organization Neuron Projection Development Aorta Development Symbiont Entry Into Host Cell Positive Regulation Of Protein Secretion Neuromuscular Process Controlling Balance Cardiac Myofibril Assembly Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Retina Development In Camera-type Eye Coronary Vasculature Development Postsynaptic Actin Cytoskeleton Organization	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Adhesion
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Integrin cell surface interactions
GWAS		Type 2 diabetes ( 30130595 )	Attention deficit hyperactivity disorder ( 18839057 )
Novel Interactors		7 novel interactors: EIF4A1 GPS2 ITGAE MYO1C SERPINF2 UBL4A XRN1	1 novel interactors: MYH10
Interacting Genes		14 interacting genes: ANXA1 APC BCAP31 DUX4 ECPAS FXR1 FXR2 MYH9 PBX1 PTEN S100A4 YWHAE YWHAG ZNF512B	5 interacting genes: CDH1 CHFR EED ITGB7 TRIM54
Entrez ID		4628	3682
HPRD ID		01178	05249
Ensembl ID		ENSG00000133026	ENSG00000083457
Uniprot IDs		A0A8I5KZ38 G1UI33 P35580	P38570
PDB IDs		4PD3	8ZJF
GO Terms Enriched among Interactors		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Protein Targeting Dentate Gyrus Development Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Primary Metabolic Process Lateral Plasma Membrane Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Cytoplasmic Stress Granule Protein Localization To Endoplasmic Reticulum Cytoplasm Translation Regulator Activity Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Meiotic Spindle Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Plasma Membrane Bounded Cell Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mononuclear Cell Differentiation Regulation Of Wound Healing Regulation Of Mitotic Cell Cycle Phase Transition Molecular Function Inhibitor Activity Negative Regulation Of Metabolic Process Cytoplasmic Translational Initiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microfilament Motor Activity Positive Regulation Of Translation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cytoplasmic Side Of Plasma Membrane Cell Adhesion Molecule Binding Symbiont Entry Into Host Cell Cell-matrix Adhesion Involved In Ameboidal Cell Migration Virus Receptor Activity Integrin Alpha4-beta7 Complex Fourth Ventricle Development Regulation Of Adaxial/abaxial Pattern Formation Meiotic Spindle Checkpoint Signaling Myosin II Filament Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Response To Heparin Cellular Response To Indole-3-methanol Cell Adhesion Cell Migration Response To Indole-3-methanol Response To Gram-positive Bacterium Lamellipodium Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Desmosome Assembly Immune Response In Gut-associated Lymphoid Tissue Biological Process Involved In Interaction With Host Third Ventricle Development Pronucleus Sex Chromatin Negative Regulation Of Meiotic Cell Cycle Phase Transition Meiotic Cell Cycle Checkpoint Signaling Flotillin Complex Positive Regulation Of Protein Transport Actomyosin Substrate-dependent Cell Migration, Cell Extension Postsynaptic Actin Cytoskeleton Ventricular Cardiac Muscle Cell Development Supramolecular Fiber GTPase Activating Protein Binding Cerebellar Purkinje Cell Layer Development Chromatin Silencing Complex Cell Motility Gamma-catenin Binding Desmosome Organization Cellular Response To Lithium Ion Positive Regulation Of Establishment Of Protein Localization Protein Localization To Membrane Adult Heart Development Cardiac Myofibril Assembly Lateral Ventricle Development ESC/E(Z) Complex Facultative Heterochromatin Formation