MYH10 and MYO1C

Number of citations: 52 (PubMedID 22939629)
Data Source: BioGRID (biochemical)

		MYH10	MYO1C
Name		myosin heavy chain 10	myosin IC
Structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Spindle Cytosol Plasma Membrane Brush Border Cell Cortex Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Myosin Complex Myosin II Complex Sarcoplasm Lamellipodium Axon Growth Cone Midbody Neuromuscular Junction Cleavage Furrow Myosin Filament Actomyosin Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Myosin II Filament Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Supramolecular Fiber	Stress Fiber Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Actin Filament Plasma Membrane Microvillus Brush Border Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Myosin Complex Unconventional Myosin Complex Nuclear Body Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Stereocilium Ruffle Membrane Cell Projection Membrane Raft Phagocytic Vesicle Stereocilium Membrane Extracellular Exosome B-WICH Complex Plasma Membrane Bounded Cell Projection
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding RNA Stem-loop Binding ADP Binding MRNA 5'-UTR Binding Actin Filament Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Small GTPase Binding Actin Filament Binding
	Biological Process	Mitotic Cytokinesis In Utero Embryonic Development Neuron Migration Plasma Membrane Repair Cardiac Septum Development Exocytosis Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Cell Adhesion Axonogenesis Axon Guidance Brain Development Heart Development Adult Heart Development Regulation Of Cell Shape Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Cerebellar Purkinje Cell Layer Development Actin Cytoskeleton Organization Actin Filament-based Movement Myofibril Assembly Actomyosin Structure Organization Neuron Projection Development Aorta Development Symbiont Entry Into Host Cell Positive Regulation Of Protein Secretion Neuromuscular Process Controlling Balance Cardiac Myofibril Assembly Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Retina Development In Camera-type Eye Coronary Vasculature Development Postsynaptic Actin Cytoskeleton Organization	Chromatin Remodeling Protein Targeting To Membrane Endocytosis Actin Filament Organization Actin Filament-based Movement Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Type II Interferon Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cellular Response To Insulin Stimulus Regulation Of Bicellular Tight Junction Assembly
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis
GWAS		Type 2 diabetes ( 30130595 )	Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 30061737 ) Mean platelet volume ( 32888494 ) Neutrophil count ( 32888494 ) Pulse pressure ( 30578418 ) White blood cell count ( 32888494 )
Novel Interactors		7 novel interactors: EIF4A1 GPS2 ITGAE MYO1C SERPINF2 UBL4A XRN1	1 novel interactors: MYH10
Interacting Genes		14 interacting genes: ANXA1 APC BCAP31 DUX4 ECPAS FXR1 FXR2 MYH9 PBX1 PTEN S100A4 YWHAE YWHAG ZNF512B	11 interacting genes: BAZ1B CBL CDC42 KHDRBS1 NEIL3 PTEN RBFOX2 RBPMS RRN3 SEPTIN9 WEE2-AS1
Entrez ID		4628	4641
HPRD ID		01178	09411
Ensembl ID		ENSG00000133026	ENSG00000197879
Uniprot IDs		A0A8I5KZ38 G1UI33 P35580	F5H6E2 O00159
PDB IDs		4PD3	4BYF
GO Terms Enriched among Interactors		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Protein Targeting Dentate Gyrus Development Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Primary Metabolic Process Lateral Plasma Membrane Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Cytoplasmic Stress Granule Protein Localization To Endoplasmic Reticulum Cytoplasm Translation Regulator Activity Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Meiotic Spindle Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Plasma Membrane Bounded Cell Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mononuclear Cell Differentiation Regulation Of Wound Healing Regulation Of Mitotic Cell Cycle Phase Transition Molecular Function Inhibitor Activity Negative Regulation Of Metabolic Process Cytoplasmic Translational Initiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microfilament Motor Activity Positive Regulation Of Translation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Alternative MRNA Splicing, Via Spliceosome Dendritic Spine Morphogenesis Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleus Localization Dendritic Spine Organization Nuclear Migration Molecular Function Inhibitor Activity Regulation Of RNA Splicing Protein Tyrosine Kinase Binding Neuron Projection Organization Postsynapse Organization Nucleic Acid Binding Establishment Of Organelle Localization Neuron Projection Morphogenesis Negative Regulation Of Synaptic Vesicle Clustering Histone H2AXY142 Kinase Activity Grb2-Sos Complex MRNA Binding MCM Complex Binding Cell Projection Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction GBD Domain Binding Storage Vacuole Fourth Ventricle Development Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity WICH Complex Negative Regulation Of Mitotic Chromosome Condensation Regulation Of MRNA Metabolic Process Neuron Projection Stress Fiber Positive Regulation Of Transport Endothelin Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Cytoskeleton-dependent Cytokinesis Myosin II Filament Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission RNA Polymerase I Core Binding SH3 Domain Binding Regulation Of Rap Protein Signal Transduction Actin Filament-based Process Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Chromosome Condensation