MYBPC2 and FSD2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MYBPC2	FSD2
Description		myosin binding protein C2	fibronectin type III and SPRY domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol M Band Myosin Filament	Nucleus Cytoplasm Sarcoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle	Protein Binding
	Biological Process	Cell Adhesion Sarcomere Organization
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS		Primary biliary cholangitis ( 26394269)	HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Tourette syndrome ( 30818990)
Interacting Genes		31 interacting genes: ACTN2 AMOT AOC3 CCT6A CMYA5 COL12A1 DST DYSF FLNB FLNC FSD2 GABARAP GAS7 HSPA1B ITGB5 MAD2L2 MSN MYBPC1 MYBPH MYH8 MYOM2 NF2 PCDH12 PDE4DIP RANBP2 SDCBP SGCG TRIM63 TRIP11 TTN TULP3	93 interacting genes: AQP1 ARFIP2 ATF7IP2 ATG14 ATXN7L2 BEX2 BEX3 BRD8 C1orf216 CAMSAP3 CBX8 CCDC112 CCDC120 CCDC146 CCDC187 CCHCR1 CDC73 CDK18 CORO1A CTAG1A CTAG1B CWF19L2 DCX DTNB ENKD1 EXOC3 FAM107A FAM110A FAM161A FAM50B FAM90A1 FARS2 FMR1 HDAC4 HGS IFT20 KANSL1 KLHL40 LATS1 LENG1 LNX1 MCRS1 MID2 MRPL11 MYBPC2 NDN OIP5 OXNAD1 PBX3 PIK3R3 PNMA5 POLL PPP1R18 PPP2R5D PRPF18 PRPF31 PSMB4 RCOR3 RNF8 SCNM1 SH2D4A SMARCE1 SNAPIN SPATC1L TCEANC THAP7 TLE5 TSGA10IP TTC23 UBTFL1 VEZF1 ZBTB38 ZC2HC1C ZMAT2 ZNF124 ZNF20 ZNF230 ZNF35 ZNF408 ZNF410 ZNF417 ZNF490 ZNF572 ZNF580 ZNF581 ZNF587 ZNF648 ZNF76 ZNF774 ZNF777 ZNF835 ZNF837 ZSCAN26
Entrez ID		4606	123722
HPRD ID		01184	17291
Ensembl ID		ENSG00000086967	ENSG00000186628
Uniprot IDs		A0A140VJQ0 Q14324	A1L4K1 B7ZM05
PDB IDs		2E7C 2EDK 2EDN
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process M Band Actin Cytoskeleton Organization Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Actomyosin Structure Organization Myosin Filament Z Disc Cytoskeletal Protein Binding Organelle Organization Actin Binding Cytoskeleton Focal Adhesion Titin Binding Positive Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Cell Adhesion Positive Regulation Of Cytoskeleton Organization Actin Filament Binding Myofibril Positive Regulation Of Microtubule Nucleation Positive Regulation Of Early Endosome To Late Endosome Transport Actin Cytoskeleton Integrin Binding Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cellular Component Biogenesis Muscle Filament Sliding Phosphatidylinositol-4,5-bisphosphate Binding Filopodium Pseudopodium Actin-myosin Filament Sliding Regulation Of Early Endosome To Late Endosome Transport Muscle Contraction Stress Fiber Regulation Of Microtubule Nucleation Regulation Of Supramolecular Fiber Organization Extracellular Exosome Calcium Ion Binding Positive Regulation Of Cellular Component Organization Plasma Membrane Enzyme Binding Muscle Cell Development Sarcolemma Muscle System Process Regulation Of Organelle Assembly Regulation Of Intracellular Transport	Zinc Ion Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Regulation Of Metabolic Process Centriole Microtubule Anchoring Microtubule Binding
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