MYBPC2 and MYH8

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MYBPC2	MYH8
Description		myosin binding protein C2	myosin heavy chain 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol M Band Myosin Filament	Cytoplasm Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Myosin Filament
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle ATP Hydrolysis Activity Myosin Phosphatase Activity Myosin Light Chain Binding Actin Filament Binding
	Biological Process	Cell Adhesion Sarcomere Organization	Skeletal Muscle Contraction Muscle Contraction Muscle Filament Sliding ATP Metabolic Process
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs
Diseases			Distal arthrogryposis (DA) Trismus-pseudocamptodactyly syndrome; Hecht-Beals Syndrome; Dutch-Kentucky syndrome
GWAS		Primary biliary cholangitis ( 26394269)	Venous thromboembolism ( 32232851)
Interacting Genes		31 interacting genes: ACTN2 AMOT AOC3 CCT6A CMYA5 COL12A1 DST DYSF FLNB FLNC FSD2 GABARAP GAS7 HSPA1B ITGB5 MAD2L2 MSN MYBPC1 MYBPH MYH8 MYOM2 NF2 PCDH12 PDE4DIP RANBP2 SDCBP SGCG TRIM63 TRIP11 TTN TULP3	1 interacting genes: MYBPC2
Entrez ID		4606	4626
HPRD ID		01184	11760
Ensembl ID		ENSG00000086967	ENSG00000133020
Uniprot IDs		A0A140VJQ0 Q14324	P13535
PDB IDs		2E7C 2EDK 2EDN
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process M Band Actin Cytoskeleton Organization Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Actomyosin Structure Organization Myosin Filament Z Disc Cytoskeletal Protein Binding Organelle Organization Actin Binding Cytoskeleton Focal Adhesion Titin Binding Positive Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Cell Adhesion Positive Regulation Of Cytoskeleton Organization Actin Filament Binding Myofibril Positive Regulation Of Microtubule Nucleation Positive Regulation Of Early Endosome To Late Endosome Transport Actin Cytoskeleton Integrin Binding Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cellular Component Biogenesis Muscle Filament Sliding Phosphatidylinositol-4,5-bisphosphate Binding Filopodium Pseudopodium Actin-myosin Filament Sliding Regulation Of Early Endosome To Late Endosome Transport Muscle Contraction Stress Fiber Regulation Of Microtubule Nucleation Regulation Of Supramolecular Fiber Organization Extracellular Exosome Calcium Ion Binding Positive Regulation Of Cellular Component Organization Plasma Membrane Enzyme Binding Muscle Cell Development Sarcolemma Muscle System Process Regulation Of Organelle Assembly Regulation Of Intracellular Transport	Structural Constituent Of Muscle M Band Sarcomere Organization Myosin Filament Actomyosin Structure Organization
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