MYBPC2 and COL12A1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MYBPC2	COL12A1
Description		myosin binding protein C2	collagen type XII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol M Band Myosin Filament	Extracellular Region Collagen Trimer Collagen Type XII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle	Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Cell Adhesion Sarcomere Organization	Cell Adhesion Tissue Development Collagen Fibril Organization Endodermal Cell Differentiation
Pathways		Striated Muscle Contraction	Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization
Drugs
Diseases
GWAS		Primary biliary cholangitis ( 26394269)	Central corneal thickness ( 29760442 32528159) Joint mobility (Beighton score) ( 27182965) Keratoconus ( 33649486) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		31 interacting genes: ACTN2 AMOT AOC3 CCT6A CMYA5 COL12A1 DST DYSF FLNB FLNC FSD2 GABARAP GAS7 HSPA1B ITGB5 MAD2L2 MSN MYBPC1 MYBPH MYH8 MYOM2 NF2 PCDH12 PDE4DIP RANBP2 SDCBP SGCG TRIM63 TRIP11 TTN TULP3	4 interacting genes: DYSF HSP90AA1 MYBPC2 WDR37
Entrez ID		4606	1303
HPRD ID		01184	00377
Ensembl ID		ENSG00000086967	ENSG00000111799
Uniprot IDs		A0A140VJQ0 Q14324	Q99715
PDB IDs		2E7C 2EDK 2EDN
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process M Band Actin Cytoskeleton Organization Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Actomyosin Structure Organization Myosin Filament Z Disc Cytoskeletal Protein Binding Organelle Organization Actin Binding Cytoskeleton Focal Adhesion Titin Binding Positive Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Cell Adhesion Positive Regulation Of Cytoskeleton Organization Actin Filament Binding Myofibril Positive Regulation Of Microtubule Nucleation Positive Regulation Of Early Endosome To Late Endosome Transport Actin Cytoskeleton Integrin Binding Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cellular Component Biogenesis Muscle Filament Sliding Phosphatidylinositol-4,5-bisphosphate Binding Filopodium Pseudopodium Actin-myosin Filament Sliding Regulation Of Early Endosome To Late Endosome Transport Muscle Contraction Stress Fiber Regulation Of Microtubule Nucleation Regulation Of Supramolecular Fiber Organization Extracellular Exosome Calcium Ion Binding Positive Regulation Of Cellular Component Organization Plasma Membrane Enzyme Binding Muscle Cell Development Sarcolemma Muscle System Process Regulation Of Organelle Assembly Regulation Of Intracellular Transport	CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Monocyte Activation Involved In Immune Response Rho GDP-dissociation Inhibitor Binding Chaperone-mediated Autophagy Sperm Mitochondrial Sheath Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Telomerase Holoenzyme Complex Assembly
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