MYBPC2 and AOC3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MYBPC2	AOC3
Description		myosin binding protein C2	amine oxidase copper containing 3
Image
GO Annotations	Cellular Component	Cytosol M Band Myosin Filament	Cytoplasm Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus Cell Surface Membrane
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Methylamine Oxidase Activity Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Quinone Binding
	Biological Process	Cell Adhesion Sarcomere Organization	Inflammatory Response Cell Adhesion Amine Metabolic Process
Pathways		Striated Muscle Contraction	Phase I - Functionalization of compounds
Drugs			Phenelzine Hydralazine 6-hydroxydopa quinone
Diseases
GWAS		Primary biliary cholangitis ( 26394269)
Interacting Genes		31 interacting genes: ACTN2 AMOT AOC3 CCT6A CMYA5 COL12A1 DST DYSF FLNB FLNC FSD2 GABARAP GAS7 HSPA1B ITGB5 MAD2L2 MSN MYBPC1 MYBPH MYH8 MYOM2 NF2 PCDH12 PDE4DIP RANBP2 SDCBP SGCG TRIM63 TRIP11 TTN TULP3	13 interacting genes: ARL13B CLDN9 CPLX4 CREB3L1 DARS2 FNDC9 HSD17B13 LMNA MYBPC2 PRRG4 SGTA STX1A VAV1
Entrez ID		4606	8639
HPRD ID		01184	04770
Ensembl ID		ENSG00000086967	ENSG00000131471
Uniprot IDs		A0A140VJQ0 Q14324	Q16853 Q9UEU7
PDB IDs		2E7C 2EDK 2EDN	1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA 4BTW 4BTX 4BTY 8S1Z
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process M Band Actin Cytoskeleton Organization Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Actomyosin Structure Organization Myosin Filament Z Disc Cytoskeletal Protein Binding Organelle Organization Actin Binding Cytoskeleton Focal Adhesion Titin Binding Positive Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Cell Adhesion Positive Regulation Of Cytoskeleton Organization Actin Filament Binding Myofibril Positive Regulation Of Microtubule Nucleation Positive Regulation Of Early Endosome To Late Endosome Transport Actin Cytoskeleton Integrin Binding Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cellular Component Biogenesis Muscle Filament Sliding Phosphatidylinositol-4,5-bisphosphate Binding Filopodium Pseudopodium Actin-myosin Filament Sliding Regulation Of Early Endosome To Late Endosome Transport Muscle Contraction Stress Fiber Regulation Of Microtubule Nucleation Regulation Of Supramolecular Fiber Organization Extracellular Exosome Calcium Ion Binding Positive Regulation Of Cellular Component Organization Plasma Membrane Enzyme Binding Muscle Cell Development Sarcolemma Muscle System Process Regulation Of Organelle Assembly Regulation Of Intracellular Transport
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