FSD2 and PSMB4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FSD2	PSMB4
Gene Name		fibronectin type III and SPRY domain containing 2	proteasome (prosome, macropain) subunit, beta type, 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Core Complex Extracellular Vesicular Exosome
	Molecular Function		Lipopolysaccharide Binding Threonine-type Endopeptidase Activity
	Biological Process		G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS			Blood trace element (Cu levels) ( 23720494)
Protein-Protein Interactions		42 interactors: AES AQP1 BEX2 BRD8 CBX8 CCDC112 CCHCR1 CDC73 CORO1A ESD FAM107A FAM161A FAM90A1 FMR1 IFT20 KANSL1 LATS1 LENG1 MRPL11 NDN NGFRAP1 PBX3 PIK3R3 POLL PPP1R18 PPP2R5D PSMB4 SH2D4A SPATC1L TCEANC ZBTB38 ZC2HC1C ZMAT2 ZNF124 ZNF20 ZNF230 ZNF410 ZNF417 ZNF572 ZNF581 ZNF587 ZSCAN26	12 interactors: APP CUL1 FSD2 OAZ1 PLK1 PRKCA PRPF19 PSMA3 PSMB5 PSMB7 PSMG3 SMAD1
Entrez ID		123722	5692
HPRD ID		17291	03710
Ensembl ID		ENSG00000186628	ENSG00000159377
Uniprot IDs		A1L4K1 B7ZM02 B7ZM05	P28070
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Wnt Signaling Pathway Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cellular Process Neurotrophin Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cellular Metabolic Process Histone Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Posterior Compartment Specification Anterior Compartment Pattern Formation Opsin Transport Histone Modification Histone H4 Acetylation Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Wnt Signaling Pathway Carbon Dioxide Transmembrane Transport Corticotropin Secretion Early Endosome To Recycling Endosome Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Respiratory Gaseous Exchange Negative Regulation Of Cellular Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Uropod Organization Metanephric Proximal Convoluted Tubule Development Nitric Oxide Transport Cellular Response To Mercury Ion Formaldehyde Catabolic Process	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cellular Amino Acid Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process Cellular Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Ubiquitination Signal Transduction In Response To DNA Damage Positive Regulation Of Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Negative Regulation Of Transferase Activity Regulation Of Proteolysis Mitotic Cell Cycle Process Cellular Protein Modification Process Mitotic Cell Cycle
Tagcloud ?			26s ac adenocarcinomas atypical carcinoid cleaved differently glioblastoma greatest investigates ki67 lcnec lcnlc microarrays neuroendocrine proliferative proteasomal psma1 psma5 psmb5 psmd1 pulmonary regardless sclc taqman tc tma tumours unlike
Tagcloud (Difference) ?			26s ac adenocarcinomas atypical carcinoid cleaved differently glioblastoma greatest investigates ki67 lcnec lcnlc microarrays neuroendocrine proliferative proteasomal psma1 psma5 psmb5 psmd1 pulmonary regardless sclc taqman tc tma tumours unlike
Tagcloud (Intersection) ?