MYBPC2 and CCT6A

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		MYBPC2	CCT6A
Name		myosin binding protein C2	chaperonin containing TCP1 subunit 6A
Structure
GO Annotations	Cellular Component	Cytosol M Band Myosin Filament	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Unfolded Protein Binding WD40-repeat Domain Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Cell Adhesion Sarcomere Organization	Protein Folding Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Striated Muscle Contraction	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle
GWAS		Primary biliary cholangitis ( 26394269 )	Coronary artery disease ( 33020668 ) Estimated glomerular filtration rate ( 31015462 ) Hip circumference adjusted for BMI ( 34021172 ) Macular telangiectasia type 2 ( 33654266 ) Plasma free amino acid levels ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 ) Systolic blood pressure ( 30224653 )
Interacting Genes		31 interacting genes: ACTN2 AMOT AOC3 CCT6A CMYA5 COL12A1 DST DYSF FLNB FLNC FSD2 GABARAP GAS7 HSPA1B ITGB5 MAD2L2 MSN MYBPC1 MYBPH MYH8 MYOM2 NF2 PCDH12 PDE4DIP RANBP2 SDCBP SGCG TRIM63 TRIP11 TTN TULP3	17 interacting genes: CEBPA DUX4 ERCC6 IMPA2 KDM5A LINC01554 MLX MYBPC2 OGT PARP4 PTEN SGCG SUMO2 SUMO4 SUPT16H TRIM31 TTN
Entrez ID		4606	908
HPRD ID		01184	00089
Ensembl ID		ENSG00000086967	ENSG00000146731
Uniprot IDs		A0A140VJQ0 Q14324	P40227
PDB IDs		2E7C 2EDK 2EDN	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
GO Terms Enriched among Interactors		Actin Filament-based Process M Band Actin Cytoskeleton Organization Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Actomyosin Structure Organization Myosin Filament Z Disc Cytoskeletal Protein Binding Organelle Organization Actin Binding Cytoskeleton Focal Adhesion Titin Binding Positive Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Cell Adhesion Positive Regulation Of Cytoskeleton Organization Actin Filament Binding Myofibril Positive Regulation Of Microtubule Nucleation Positive Regulation Of Early Endosome To Late Endosome Transport Actin Cytoskeleton Integrin Binding Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cellular Component Biogenesis Muscle Filament Sliding Phosphatidylinositol-4,5-bisphosphate Binding Filopodium Pseudopodium Actin-myosin Filament Sliding Regulation Of Early Endosome To Late Endosome Transport Muscle Contraction Stress Fiber Regulation Of Microtubule Nucleation Regulation Of Supramolecular Fiber Organization Extracellular Exosome Calcium Ion Binding Positive Regulation Of Cellular Component Organization Plasma Membrane Enzyme Binding Muscle Cell Development Sarcolemma Muscle System Process Regulation Of Organelle Assembly Regulation Of Intracellular Transport	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Chromatin DNA Binding Regulation Of RNA Metabolic Process Protein Tag Activity Positive Regulation Of Transcription By RNA Polymerase II Response To Lithium Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Elongation Factor Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Gene Expression M Band Circadian Rhythm Ubiquitin-like Protein Ligase Binding Negative Regulation Of Cell Cycle Regulation Of Peptidyl-serine Phosphorylation Regulation Of Proteolysis Protein Modification Process Sarcomere Organization Structural Constituent Of Muscle Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Macromolecule Metabolic Process Protein Sumoylation Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation Nucleoplasm Inflammatory Response Response To Vitamin B2 C/EBP Complex Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Glycerol-2-phosphatase Activity