MUTYH and APEX1

Number of citations of the paper that reports this interaction (PubMedID 11092888)
0

Data Source:
HPRD (in vitro, in vivo)

		MUTYH	APEX1
Description		mutY DNA glycosylase	apurinic/apyrimidinic endodeoxyribonuclease 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Binding Catalytic Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	DNA Binding Damaged DNA Binding Double-stranded Telomeric DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity 3'-5'-DNA Exonuclease Activity Double-stranded DNA Exodeoxyribonuclease Activity Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Hydrolase Activity Chromatin DNA Binding Deoxyribonuclease (pyrimidine Dimer) Activity Metal Ion Binding Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands DNA-(abasic Site) Binding
	Biological Process	DNA Repair Base-excision Repair Mismatch Repair Response To Stress DNA Damage Response Depurination Negative Regulation Of Necroptotic Process	Telomere Maintenance DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Catabolic Process DNA Recombination DNA Damage Response Regulation Of Apoptotic Process Regulation Of MRNA Stability Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Cell Redox Homeostasis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Base-excision Repair
Pathways			Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs			Lucanthone
Diseases		Familial adenomatous polyposis
GWAS		Composite immunoglobulin trait (IgA/IgM) ( 28628107) Periventricular white matter hyperintensities ( 32517579)	Menopause (age at onset) ( 26414677)
Interacting Genes		19 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TSTD2 XPA	46 interacting genes: ANP32A ANP32CP APP CDC42 CEBPA CSNK2A1 DCTN1 EP300 FBXO7 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A LINC01554 MCL1 MDM2 MUTYH NFE2L2 NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SLC25A21-AS1 SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I UBR3 XRCC1 XRCC5 XRCC6
Entrez ID		4595	328
HPRD ID		05380	00136
Ensembl ID		ENSG00000132781	ENSG00000100823
Uniprot IDs		A0AAQ5BGW7 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 E9PP34 Q9UIF7	P27695 Q5TZP7
PDB IDs		1X51 3N5N 8FAY	1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0 5WN0 5WN1 5WN2 5WN3 5WN4 5WN5 6BOQ 6BOR 6BOS 6BOT 6BOU 6BOV 6BOW 6MK3 6MKK 6MKM 6MKO 6P93 6P94 6W0Q 6W2P 6W3L 6W3N 6W3Q 6W3U 6W43 6W4I 6W4T 7LPG 7LPH 7LPI 7LPJ 7MCR 7MEV 7SUV 7SVB 7TC2 7TC3 7TR7 7U50 9DP1 9DP2 9DP3 9DP4
Enriched GO Terms of Interacting Partners?		Damaged DNA Binding Base-excision Repair DNA Repair Nucleotide-excision Repair DNA Replication Factor A Complex DNA Metabolic Process DNA Damage Response Chromosome, Telomeric Region Cellular Response To Stress Mismatch Repair Site Of Double-strand Break Response To Stress Response To UV MutLalpha Complex Binding Male Germ Cell Nucleus Chromosome Organization Nuclear Lamina Base-excision Repair, Gap-filling Response To Radiation DNA Recombination Telomere Maintenance Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Telomere Organization Protein Localization To Site Of Double-strand Break Response To Light Stimulus DNA Replication Protein Localization To Organelle Determination Of Adult Lifespan Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Glycine N-choloyltransferase Activity Bile Acid Conjugation Meiotic Mismatch Repair Intrinsic Apoptotic Signaling Pathway Cellular Response To Radiation Protein Localization To Nucleus PCNA Complex Replisome Site Of DNA Damage Nucleotide-excision Repair, DNA Damage Recognition Endoplasmic Reticulum Sec Complex Histone H3K56 Deacetylase Activity, NAD-dependent Negative Regulation Of Cell Population Proliferation DNA-(abasic Site) Binding Nucleoplasm Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Nucleic Acid Metabolic Process DNA Metabolic Process 5'-deoxyribose-5-phosphate Lyase Activity Protein-containing Complex DNA Damage Response Damaged DNA Binding Nuclear Telomere Cap Complex Macromolecule Metabolic Process Enzyme Binding Negative Regulation Of DNA Metabolic Process Cellular Response To Stress Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Telomere Maintenance Negative Regulation Of Metabolic Process DNA Binding Base-excision Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Response To Stress Chromosome Organization Transcription Cis-regulatory Region Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Telomere Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Double-stranded Telomeric DNA Binding DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Telomeric DNA Binding Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Biosynthetic Process Response To Radiation Chromosome, Telomeric Region Regulation Of Primary Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process DNA Binding, Bending Protein-DNA Complex Double-strand Break Repair DNA Biosynthetic Process
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