MUTYH

Gene Name		mutY homolog
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Depurination
Pathways		Depurination Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Base-Excision Repair, AP Site Formation Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: AGTRAP APEX1 LRSAM1 MSH6 PCNA RPA1 RPA4
Entrez ID		4595
HPRD ID		05380
Ensembl ID		ENSG00000132781
Uniprot IDs		D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 Q9UIF7
PDB IDs		1X51 3N5N
Enriched GO Terms of Interacting Partners?		Mismatch Repair DNA Recombination Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling DNA-dependent DNA Replication Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair DNA Repair DNA Replication Base-excision Repair Cellular Response To DNA Damage Stimulus Telomere Maintenance Cell Cycle Process DNA Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle Cellular Response To Stress Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Deoxyribonuclease Activity Ubiquitin-dependent Endocytosis Leading Strand Elongation Organelle Organization DNA Catabolic Process Mitotic Cell Cycle Process Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Homeostasis Meiotic Mismatch Repair Meiotic Nuclear Division DNA Recombinase Assembly Meiotic Cell Cycle Positive Regulation Of Helicase Activity Angiotensin-activated Signaling Pathway Chromosome Organization Cellular Response To Stimulus Viral Budding Response To Abiotic Stimulus Translesion Synthesis Aging
Tagcloud ?		2014genetics actionable advance atm cdkn2a chek2 counseling definitively deleterious doi genet germ gim guidelines heterozygote heterozygous identifies massively med msh2 online parallel pretest publication reportable susceptibility uncertain variant variants