MUTYH and MSH6

Number of citations of the paper that reports this interaction (PMID 11801590)
42

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MUTYH	MSH6
Gene Name		mutY homolog	mutS homolog 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nuclear Chromosome Nuclear Chromatin Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane MutSalpha Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Magnesium Ion Binding Four-way Junction DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity ATPase Activity Mismatched DNA Binding Guanine/thymine Mispair Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Methylated Histone Binding Protein Homodimerization Activity ADP Binding
	Biological Process	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Depurination	Meiotic Mismatch Repair DNA Repair Mismatch Repair Reciprocal Meiotic Recombination Determination Of Adult Lifespan Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway
Pathways		Depurination Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Base-Excision Repair, AP Site Formation Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Resolution of Abasic Sites (AP sites)	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AGTRAP APEX1 LRSAM1 MSH6 PCNA RPA1 RPA4	13 interactors: BARD1 BRCA1 CHAF1A CREBBP CSNK2A1 EP300 HUS1 MSH2 MUTYH PCNA RAD1 RAD9A SMC1A
Entrez ID		4595	2956
HPRD ID		05380	07202
Ensembl ID		ENSG00000132781	ENSG00000116062
Uniprot IDs		D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 Q9UIF7	B4DF41 B4E3I4 F5H2F9 P52701 Q3SWU9
PDB IDs		1X51 3N5N	2GFU 2O8B 2O8C 2O8D 2O8E 2O8F
Enriched GO Terms of Interacting Partners?		Mismatch Repair DNA Recombination Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling DNA-dependent DNA Replication Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair DNA Repair DNA Replication Base-excision Repair Cellular Response To DNA Damage Stimulus Telomere Maintenance Cell Cycle Process DNA Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle Cellular Response To Stress Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Deoxyribonuclease Activity Ubiquitin-dependent Endocytosis Leading Strand Elongation Organelle Organization DNA Catabolic Process Mitotic Cell Cycle Process Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Homeostasis Meiotic Mismatch Repair Meiotic Nuclear Division DNA Recombinase Assembly Meiotic Cell Cycle Positive Regulation Of Helicase Activity Angiotensin-activated Signaling Pathway Chromosome Organization Cellular Response To Stimulus Viral Budding Response To Abiotic Stimulus Translesion Synthesis Aging	Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress Cell Cycle Cell Cycle Process DNA Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Response To Ionizing Radiation DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Response To Abiotic Stimulus Mitotic Cell Cycle Process Mitotic Cell Cycle Cellular Response To Stimulus Response To Radiation Negative Regulation Of Mitotic Cell Cycle Postreplication Repair N-terminal Peptidyl-lysine Acetylation Response To Stimulus Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Mismatch Repair Regulation Of Cell Cycle Process Cellular Response To Ionizing Radiation DNA Recombination Protein K6-linked Ubiquitination Chromosome Organization Negative Regulation Of Cell Division Intra-S DNA Damage Checkpoint Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process N-terminal Protein Amino Acid Acetylation Negative Regulation Of DNA Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of DNA Replication DNA Catabolic Process Cellular Response To Radiation Negative Regulation Of Meiotic Nuclear Division
Tagcloud ?		2014genetics actionable advance atm cdkn2a chek2 counseling definitively deleterious doi genet germ gim guidelines heterozygote heterozygous identifies massively med msh2 online parallel pretest publication reportable susceptibility uncertain variant variants	aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e
Tagcloud (Difference) ?		2014genetics actionable advance atm cdkn2a chek2 counseling definitively deleterious doi genet germ gim guidelines heterozygote heterozygous identifies massively med msh2 online parallel pretest publication reportable susceptibility uncertain variant variants	aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e
Tagcloud (Intersection) ?