MUTYH and RPA4

Number of citations of the paper that reports this interaction (PMID 11092888)
44

Data Source:
HPRD (in vivo, in vitro)

		MUTYH	RPA4
Gene Name		mutY homolog	replication protein A4, 30kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nucleus Nucleoplasm DNA Replication Factor A Complex
	Molecular Function	Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Single-stranded DNA Binding
	Biological Process	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Depurination	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Nucleotide-excision Repair DNA Recombination Nuclear DNA Replication
Pathways		Depurination Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Base-Excision Repair, AP Site Formation Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Resolution of Abasic Sites (AP sites)	G1/S Transition Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AGTRAP APEX1 LRSAM1 MSH6 PCNA RPA1 RPA4	7 interactors: APP MSH2 MSH3 MUTYH RPA1 RPA3 XPA
Entrez ID		4595	29935
HPRD ID		05380	06591
Ensembl ID		ENSG00000132781	ENSG00000204086
Uniprot IDs		D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 Q9UIF7	Q13156
PDB IDs		1X51 3N5N
Enriched GO Terms of Interacting Partners?		Mismatch Repair DNA Recombination Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling DNA-dependent DNA Replication Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair DNA Repair DNA Replication Base-excision Repair Cellular Response To DNA Damage Stimulus Telomere Maintenance Cell Cycle Process DNA Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle Cellular Response To Stress Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Deoxyribonuclease Activity Ubiquitin-dependent Endocytosis Leading Strand Elongation Organelle Organization DNA Catabolic Process Mitotic Cell Cycle Process Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Homeostasis Meiotic Mismatch Repair Meiotic Nuclear Division DNA Recombinase Assembly Meiotic Cell Cycle Positive Regulation Of Helicase Activity Angiotensin-activated Signaling Pathway Chromosome Organization Cellular Response To Stimulus Viral Budding Response To Abiotic Stimulus Translesion Synthesis Aging	Mismatch Repair DNA Repair Nucleotide-excision Repair, DNA Damage Removal Cellular Response To DNA Damage Stimulus DNA Catabolic Process DNA Metabolic Process Meiotic Mismatch Repair DNA Recombination Maintenance Of DNA Repeat Elements Cellular Response To Stress Base-excision Repair DNA Recombinase Assembly Positive Regulation Of Helicase Activity Response To Stress Nucleotide-excision Repair Response To Abiotic Stimulus Aromatic Compound Catabolic Process Double-strand Break Repair Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Metabolic Process Meiotic Nuclear Division Telomere Maintenance Via Semi-conservative Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of DNA Recombination Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Nitrogen Compound Metabolic Process Meiotic Cell Cycle Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Nitrogen Compound Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cellular Macromolecule Catabolic Process Transcription-coupled Nucleotide-excision Repair Response To Light Stimulus Chromosome Organization Reproduction Cell Cycle Process Cellular Response To Stimulus Immunoglobulin Production Cellular Response To Heat Regulation Of DNA Recombination Regulation Of Mitotic Cell Cycle Telomere Maintenance Response To Radiation
Tagcloud ?		2014genetics actionable advance atm cdkn2a chek2 counseling definitively deleterious doi genet germ gim guidelines heterozygote heterozygous identifies massively med msh2 online parallel pretest publication reportable susceptibility uncertain variant variants
Tagcloud (Difference) ?		2014genetics actionable advance atm cdkn2a chek2 counseling definitively deleterious doi genet germ gim guidelines heterozygote heterozygous identifies massively med msh2 online parallel pretest publication reportable susceptibility uncertain variant variants
Tagcloud (Intersection) ?