EIF2AK4 and ARRB1

Number of citations of the paper that reports this interaction (PubMedID 25589675)
54

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		EIF2AK4	ARRB1
Description		eukaryotic translation initiation factor 2 alpha kinase 4	arrestin beta 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytosolic Ribosome	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Membrane Nuclear Body Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Cell Projection
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	G Protein-coupled Receptor Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Molecular Adaptor Activity Arrestin Family Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Adaptive Immune Response Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Protein Phosphorylation Nervous System Development Learning Long-term Memory Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Viral Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of CREB Transcription Factor Activity Cellular Response To Amino Acid Starvation Cellular Response To UV Response To Endoplasmic Reticulum Stress Host-mediated Suppression Of Viral Genome Replication Negative Regulation Of Neuron Differentiation Negative Regulation Of Translational Initiation Protein Autophosphorylation Defense Response To Virus Regulation Of Cell Cycle Regulation Of Feeding Behavior Cellular Response To Cold Positive Regulation Of Translational Initiation In Response To Starvation GCN2-mediated Signaling Positive Regulation Of Long-term Synaptic Potentiation Neuron Projection Extension	Positive Regulation Of Protein Phosphorylation Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Signal Transduction Sensory Perception Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Protein Transport Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction
Pathways		Response of EIF2AK4 (GCN2) to amino acid deficiency	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling
Drugs		Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Body mass index ( 24827717) Corneal curvature ( 22969067) Diastolic blood pressure ( 27841878) Ewing sarcoma ( 22327514) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Response to haloperidol in psychosis ( 24751813) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure ( 30578418 27841878)	Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		7 interacting genes: ARRB1 ARRB2 GGNBP1 RNF10 SMAD1 SMAD4 TGFBR1	58 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CRHR1 CSK CXCR2 CYTH2 DVL1 DVL2 EIF2AK4 FGR FLNA GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEDD4L NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 POU2F1 PRDM16 PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SNCA SREBF2 TIAM1 TP53 TRHR ZBTB43
Entrez ID		440275	408
HPRD ID		18447	00146
Ensembl ID		ENSG00000128829	ENSG00000137486
Uniprot IDs		Q9P2K8	B7Z1Q3 P49407
PDB IDs		6N3L 6N3N 6N3O 7E2K 7E2M 7QQ6 7QWK 8T7T	2IV8 6PWC 6TKO 6UP7 7R0C 7R0J 7SRS 8AS2 8AS3 8AS4 8JRV 8WRZ 9II2 9II3
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Angiotensin Receptor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Cardiac Muscle Hypertrophy SMAD Protein Complex Heteromeric SMAD Protein Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation G Protein-coupled Receptor Internalization Cardiac Conduction System Development Positive Regulation Of Cellular Component Organization Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Multicellular Organismal Process Regulation Of Extracellular Matrix Assembly Regulation Of System Process Cell Fate Commitment SMAD Protein Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Receptor Internalization Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macromolecule Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Post-translational Protein Modification Regulation Of Muscle System Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Differentiation Ventricular Septum Morphogenesis Neuron Fate Commitment Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Growth Factor Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Postsynaptic Signal Transduction Transcription By RNA Polymerase II	Signal Transduction Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Regulation Of Transport Regulation Of Signaling Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane Protein Kinase Activity Cytosol Regulation Of Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Protein Phosphorylation Regulation Of Multicellular Organismal Process Endocytosis Positive Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport G Protein-coupled Receptor Activity Regulation Of Cellular Component Organization Phosphorylation Positive Regulation Of Organelle Organization Immune Response-regulating Signaling Pathway Import Into Cell Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Endocytosis Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Receptor Internalization Positive Regulation Of Cell Communication Regulation Of Cytoskeleton Organization MAP Kinase Activity Regulation Of MAPK Cascade Regulation Of Organelle Organization Protein Serine Kinase Activity Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Neuronal Dense Core Vesicle MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Localization
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