EIF2AK4 and ARRB2

Number of citations of the paper that reports this interaction (PubMedID 25589675)
54

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		EIF2AK4	ARRB2
Description		eukaryotic translation initiation factor 2 alpha kinase 4	arrestin beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytosolic Ribosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Endocytic Vesicle Membrane Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding D1 Dopamine Receptor Binding Protein Kinase B Binding Molecular Adaptor Activity
	Biological Process	DNA Damage Checkpoint Signaling Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Adaptive Immune Response Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Protein Phosphorylation Nervous System Development Learning Long-term Memory Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Viral Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of CREB Transcription Factor Activity Cellular Response To Amino Acid Starvation Cellular Response To UV Response To Endoplasmic Reticulum Stress Host-mediated Suppression Of Viral Genome Replication Negative Regulation Of Neuron Differentiation Negative Regulation Of Translational Initiation Protein Autophosphorylation Defense Response To Virus Regulation Of Cell Cycle Regulation Of Feeding Behavior Cellular Response To Cold Positive Regulation Of Translational Initiation In Response To Starvation GCN2-mediated Signaling Positive Regulation Of Long-term Synaptic Potentiation Neuron Projection Extension	Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Adult Walking Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Protein Transport Protein Ubiquitination Sensory Perception Of Pain Negative Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Postsynaptic Signal Transduction Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Response of EIF2AK4 (GCN2) to amino acid deficiency	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling
Drugs		Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Body mass index ( 24827717) Corneal curvature ( 22969067) Diastolic blood pressure ( 27841878) Ewing sarcoma ( 22327514) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Response to haloperidol in psychosis ( 24751813) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure ( 30578418 27841878)	Behcet's disease ( 33393726) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: ARRB1 ARRB2 GGNBP1 RNF10 SMAD1 SMAD4 TGFBR1	60 interacting genes: ADRB2 AGTR1 AGTR2 AP1B1 AP2M1 ARF6 AVPR2 BCAS1 C5AR1 CDC42 CLTC CRHR1 CSNK2A1 CSNK2A2 CXCR4 CYTH2 DLG4 DVL2 EGFR EIF2AK4 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MAS1 MDM2 MED8 NDUFS7 NEDD4L NFKBIA NTS NTSR1 OPRD1 OXER1 OXTR PDE4D PTAFR PTGDS RAF1 RALGDS RHO SLC9A5 SMARCC2 SNCA STC2 SUMO1 SUMO2 TGFBR3 TRH UBC UBE2I
Entrez ID		440275	409
HPRD ID		18447	00147
Ensembl ID		ENSG00000128829	ENSG00000141480
Uniprot IDs		Q9P2K8	K7ENA6 P32121 Q59EM5 Q68DZ5
PDB IDs		6N3L 6N3N 6N3O 7E2K 7E2M 7QQ6 7QWK 8T7T
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Angiotensin Receptor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Cardiac Muscle Hypertrophy SMAD Protein Complex Heteromeric SMAD Protein Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation G Protein-coupled Receptor Internalization Cardiac Conduction System Development Positive Regulation Of Cellular Component Organization Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Multicellular Organismal Process Regulation Of Extracellular Matrix Assembly Regulation Of System Process Cell Fate Commitment SMAD Protein Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Receptor Internalization Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macromolecule Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Post-translational Protein Modification Regulation Of Muscle System Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Differentiation Ventricular Septum Morphogenesis Neuron Fate Commitment Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Growth Factor Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Postsynaptic Signal Transduction Transcription By RNA Polymerase II	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of Biological Quality Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase Activity Clathrin-coated Endocytic Vesicle Membrane Angiotensin Type II Receptor Activity Regulation Of Transport Positive Regulation Of Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Metal Ion Transport Regulation Of MAPK Cascade Regulation Of System Process Regulation Of Systemic Arterial Blood Pressure Glutamatergic Synapse Regulation Of Developmental Process Positive Regulation Of Locomotion Negative Regulation Of Systemic Arterial Blood Pressure Ubiquitin Protein Ligase Binding Enzyme Binding Blood Vessel Diameter Maintenance Regulation Of Tube Size Kinase Activity Import Into Cell Postsynapse Regulation Of Monoatomic Ion Transport Response To Stress Regulation Of Blood Pressure Neuron Spine Positive Regulation Of Neuron Projection Arborization Endocytosis Positive Regulation Of Cell Migration
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