MRC1 and CHEK2

Number of citations of the paper that reports this interaction (PMID 11715017)
83

Data Source:
HPRD (two hybrid)

		MRC1	CHEK2
Gene Name		mannose receptor, C type 1	checkpoint kinase 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane	Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus PML Body
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Mannose Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Receptor-mediated Endocytosis Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-4	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) Hematological and biochemical traits ( 20139978)	Breast cancer ( 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		1 interactors: CHEK2	47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL
Entrez ID		4360	11200
HPRD ID		01089	05084
Ensembl ID		ENSG00000120586	ENSG00000183765
Uniprot IDs		P22897	O96017
PDB IDs		1EGG 1EGI	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		Signal Transduction Involved In Intra-S DNA Damage Checkpoint Regulation Of Nuclear Cell Cycle DNA Replication Intra-S DNA Damage Checkpoint DNA Damage Induced Protein Phosphorylation Replicative Senescence Mitotic Spindle Assembly Mitotic Spindle Organization Negative Regulation Of DNA Replication Response To Gamma Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cell Aging Spindle Assembly Protein Stabilization Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Spindle Organization Regulation Of Protein Stability Response To Ionizing Radiation Double-strand Break Repair DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Intrinsic Apoptotic Signaling Pathway Protein Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Nuclear Division Aging Apoptotic Signaling Pathway	Cellular Response To DNA Damage Stimulus Cell Cycle Process Cellular Response To Stress Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Process DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Checkpoint Response To Stress Signal Transduction By P53 Class Mediator DNA Repair Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Response To Stimulus Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Negative Regulation Of Cell Cycle Apoptotic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Programmed Cell Death Mitotic DNA Damage Checkpoint Regulation Of Protein Metabolic Process Double-strand Break Repair Mitotic DNA Integrity Checkpoint Cell Death Death Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Response To Abiotic Stimulus Signal Transduction DNA Recombination Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Signaling Nucleobase-containing Compound Metabolic Process Cell Communication Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?		accomplished annotated borderline cartilage comp csmd1 discrimination genotyping hampered hip indication influencing knee loci meta oa oligomeric osteoarthritis residuals rs10038 rs1983474 rs691461 scomp snp standardised telopeptide treatoa uctx wide	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		accomplished annotated borderline cartilage comp csmd1 discrimination genotyping hampered hip indication influencing knee loci meta oa oligomeric osteoarthritis residuals rs10038 rs1983474 rs691461 scomp standardised telopeptide treatoa uctx wide	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?		snp