MRC1

Description		mannose receptor C-type 1
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GO Annotations	Cellular Component	Endosome Plasma Membrane Cell Surface Endosome Membrane Membrane
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Signaling Receptor Activity Cargo Receptor Activity
	Biological Process	Endocytosis Receptor-mediated Endocytosis Symbiont Entry Into Host Cell Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-4
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Modulation by Mtb of host immune system
Drugs		Technetium Tc-99m tilmanocept
Diseases
GWAS		Aspartate aminotransferase levels ( 29403010 33339817) Blood protein levels ( 30072576) Cardiovascular disease risk factors ( 21943158) Childhood and early adolescence aggressive behavior ( 26087016) Hematological and biochemical traits ( 20139978) Osteoarthritis biomarkers ( 25057126)
Interacting Genes		1 interacting genes: CHEK2
Entrez ID		4360
HPRD ID		01089
Ensembl ID		ENSG00000260314
Uniprot IDs		P22897
PDB IDs		1EGG 1EGI 5XTS 5XTW 6INN 6INO 6INU 6INV 6IOE 7JUB 7JUC 7JUD 7JUE 7JUF 7JUG 7JUH 7L61 7L62 7L63 7L64 7L65 7L66 7L67 7L68
Enriched GO Terms of Interacting Partners?		Response To Glycoside Negative Regulation Of DNA Damage Checkpoint Response To Bisphenol A Cellular Response To Bisphenol A Positive Regulation Of Anoikis Thymocyte Apoptotic Process Replicative Senescence Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Vacuole Organization Positive Regulation Of Autophagosome Assembly Regulation Of DNA Damage Checkpoint T Cell Apoptotic Process Regulation Of Anoikis Cellular Response To Gamma Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Lymphocyte Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Autophagosome Assembly Leukocyte Apoptotic Process Mitotic Spindle Assembly Response To Gamma Radiation G2/M Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Cycle G2/M Phase Transition Regulation Of Vacuole Organization Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Xenobiotic Stimulus Protein K63-linked Ubiquitination Cellular Response To Ionizing Radiation Mitotic DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Macroautophagy Autophagosome Organization Mitotic Spindle Organization Positive Regulation Of Organelle Assembly Autophagosome Assembly Signal Transduction By P53 Class Mediator Spindle Assembly DNA Damage Checkpoint Signaling PML Body Positive Regulation Of Cell Cycle Phase Transition Protein Autophosphorylation Regulation Of Signal Transduction By P53 Class Mediator Microtubule Cytoskeleton Organization Involved In Mitosis Response To Ionizing Radiation Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Vacuole Organization Spindle Organization Positive Regulation Of Autophagy
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