CIITA and SMARCA4

Number of citations of the paper that reports this interaction (PMID 12077331)
15

Data Source:
BioGRID (pull down, pull down)

		CIITA	SMARCA4
Gene Name		class II, major histocompatibility complex, transactivator	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm PML Body	Nuclear Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Nucleolus Membrane SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Kinase Activity Transferase Activity, Transferring Acyl Groups Protein Complex Binding Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Immune Response Phosphorylation Cytokine-mediated Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Antibiotic Interferon-gamma-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Vasculogenesis Blastocyst Growth Blastocyst Hatching Liver Development Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Methylation-dependent Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Glial Cell Fate Determination DNA Methylation On Cytosine Within A CG Sequence Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Keratinocyte Differentiation Negative Regulation Of Cell Growth Forebrain Development Hindbrain Development Embryonic Hindlimb Morphogenesis Aortic Smooth Muscle Cell Differentiation ATP-dependent Chromatin Remodeling Positive Regulation Of DNA Binding Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Epidermis Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Definitive Erythrocyte Differentiation Heart Trabecula Formation Negative Regulation Of Androgen Receptor Signaling Pathway Lens Fiber Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer RMTs methylate histone arginines
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Ulcerative colitis ( 20228799)	Coronary heart disease ( 21347282)
Protein-Protein Interactions		17 interactors: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC	73 interactors: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHMP5 CIITA CREB1 CTNNB1 DPF3 ESR1 ETS2 FANCA GATA1 GMNN H2AFX H3F3A HIST1H3A HIST1H4F HIST2H2BE HIST2H3C HSF1 HSF4 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MKL1 MPHOSPH6 MPP6 MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SS18 SS18L1 STAT2 STAT3 STK11 TMF1 TP53 ZMYND11
Entrez ID		4261	6597
HPRD ID		02475	04459
Ensembl ID		ENSG00000179583	ENSG00000127616
Uniprot IDs		E9PFE0 P33076 Q66X48	A7E2E1 B3KNW7 P51532 Q9HBD4
PDB IDs			2GRC 2H60 3UVD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Histone Modification Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Chromatin Modification Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Peptidyl-amino Acid Modification Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Histone H4 Deacetylation Regulation Of Protein Export From Nucleus Peptidyl-lysine Modification Regulation Of Binding Histone Acetylation Transcription From RNA Polymerase II Promoter Internal Peptidyl-lysine Acetylation Viral Process Peptidyl-lysine Acetylation Negative Regulation Of Biosynthetic Process Internal Protein Amino Acid Acetylation Response To Organic Substance	Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Organelle Organization Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Anatomical Structure Development Developmental Process Chromatin Assembly Or Disassembly System Development Multicellular Organismal Development ATP-dependent Chromatin Remodeling
Tagcloud ?		absent additionally allograft assayed class constitutively derepression fetal gamma histocompatibility ifn inducer lesion mhc neither preventing problem promoters rejection rfx suppression transactivator transfected transfection trophoblast trophoblasts vector x2bp	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?		absent additionally allograft assayed class constitutively derepression fetal gamma histocompatibility ifn inducer lesion mhc neither preventing problem promoters rejection rfx suppression transactivator transfected transfection trophoblast trophoblasts vector x2bp	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?