CIITA and NFYB

Number of citations of the paper that reports this interaction (PMID 11003667)
23

Data Source:
HPRD (in vivo)

		CIITA	NFYB
Gene Name		class II, major histocompatibility complex, transactivator	nuclear transcription factor Y, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm PML Body	Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Kinase Activity Transferase Activity, Transferring Acyl Groups Protein Complex Binding Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Immune Response Phosphorylation Cytokine-mediated Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Antibiotic Interferon-gamma-mediated Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins ATF4 activates genes ATF6-alpha activates chaperone genes Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) PERK regulates gene expression ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Ulcerative colitis ( 20228799)
Protein-Protein Interactions		17 interactors: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC	24 interactors: AGTRAP C1QBP CEBPZ CIITA CNTN2 DRAP1 ELF1 EP300 GRB2 MAOB MYC NFYA NFYC POLE4 SMYD3 SP1 TAF11 TAF12 TAF6 TBP TP53 TP73 YBX1 YBX3
Entrez ID		4261	4801
HPRD ID		02475	01794
Ensembl ID		ENSG00000179583	ENSG00000120837
Uniprot IDs		E9PFE0 P33076 Q66X48	P25208
PDB IDs			1N1J 4AWL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Histone Modification Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Chromatin Modification Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Peptidyl-amino Acid Modification Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Histone H4 Deacetylation Regulation Of Protein Export From Nucleus Peptidyl-lysine Modification Regulation Of Binding Histone Acetylation Transcription From RNA Polymerase II Promoter Internal Peptidyl-lysine Acetylation Viral Process Peptidyl-lysine Acetylation Negative Regulation Of Biosynthetic Process Internal Protein Amino Acid Acetylation Response To Organic Substance	Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation By Host Of Viral Transcription Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Interaction With Symbiont Negative Regulation Of Signal Transduction Cellular Response To Radiation Negative Regulation Of Signaling Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Tagcloud ?		absent additionally allograft assayed class constitutively derepression fetal gamma histocompatibility ifn inducer lesion mhc neither preventing problem promoters rejection rfx suppression transactivator transfected transfection trophoblast trophoblasts vector x2bp	attenuates behave caf ccaat competes concordance conversely counteracts deacetylase deltanp73 deltanp73alpha detecting exist hdac hdac1 immunofluorescence motif nih3t3 p73 p73alpha pdgfrb periods repression starved supporting tap73 trichostatin yc
Tagcloud (Difference) ?		absent additionally allograft assayed class constitutively derepression fetal gamma histocompatibility ifn inducer lesion mhc neither preventing problem promoters rejection rfx suppression transactivator transfected transfection trophoblast trophoblasts vector x2bp	attenuates behave caf ccaat competes concordance conversely counteracts deacetylase deltanp73 deltanp73alpha detecting exist hdac hdac1 immunofluorescence motif nih3t3 p73 p73alpha pdgfrb periods repression starved supporting tap73 trichostatin yc
Tagcloud (Intersection) ?