CIITA

Name	class II major histocompatibility complex transactivator
Structure	No pdb structure
Interactors	18 interactors: CDK1 CREBBP GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol PML Body
	Molecular Function	Nucleotide Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Acyltransferase Activity Histone Deacetylase Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Immune Response Negative Regulation Of Collagen Biosynthetic Process Response To Type II Interferon Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Suppression Of Symbiont Invasion Response To Antibiotic Type II Interferon-mediated Signaling Pathway
Pathways	Interferon gamma signaling
Diseases	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2
GWAS	Alopecia areata ( 25608926 ) Asthma ( 31619474 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Celiac disease ( 20190752 22057235 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Nasopharyngeal carcinoma ( 27436580 ) Systemic lupus erythematosus ( 26502338 27399966 ) Ulcerative colitis ( 20228799 )
Entrez ID	4261
HPRD ID	02475
Ensembl ID	ENSG00000179583
Uniprot IDs	A0A087X2I7 P33076 Q66X48
PDB IDs	Not available
GO Terms Enriched among Interactors ?	DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Organization Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process P53 Binding Transcription Coactivator Activity Protein-lysine-acetyltransferase Activity Nucleus Regulation Of Macromolecule Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Rhythmic Process Regulation Of Metabolic Process Histone Deacetylase Binding Regulation Of Generation Of Precursor Metabolites And Energy RNA Polymerase II Transcription Regulator Complex Protein Lysine Deacetylase Activity Chromatin Binding Transcription Preinitiation Complex Assembly Negative Regulation Of Myotube Differentiation Negative Regulation Of Macromolecule Metabolic Process Acetyltransferase Activity Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding SAGA Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Regulation Of DNA Repair Transcription Factor TFIID Complex Protein Acetylation