CIITA and TAF6

Number of citations of the paper that reports this interaction (PMID 9177216)
28

Data Source:
HPRD (in vitro)

		CIITA	TAF6
Gene Name		class II, major histocompatibility complex, transactivator	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm PML Body	Nucleus Nucleoplasm Transcription Factor TFIID Complex Cytoplasm Transcription Factor TFTC Complex MLL1 Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Kinase Activity Transferase Activity, Transferring Acyl Groups Protein Complex Binding Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Immune Response Phosphorylation Cytokine-mediated Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Antibiotic Interferon-gamma-mediated Signaling Pathway	DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Gene Expression Viral Process Negative Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Ulcerative colitis ( 20228799)
Protein-Protein Interactions		17 interactors: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC	24 interactors: AHR APP CIITA GTF2E1 HIST3H3 HNF4A NCOR1 NFYA NFYB NFYC NR1D2 RELA SH3KBP1 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF7 TAF8 TAF9 TAF9B
Entrez ID		4261	6878
HPRD ID		02475	11807
Ensembl ID		ENSG00000179583	ENSG00000106290
Uniprot IDs		E9PFE0 P33076 Q66X48	P49848
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Histone Modification Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Chromatin Modification Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Peptidyl-amino Acid Modification Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Histone H4 Deacetylation Regulation Of Protein Export From Nucleus Peptidyl-lysine Modification Regulation Of Binding Histone Acetylation Transcription From RNA Polymerase II Promoter Internal Peptidyl-lysine Acetylation Viral Process Peptidyl-lysine Acetylation Negative Regulation Of Biosynthetic Process Internal Protein Amino Acid Acetylation Response To Organic Substance	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Viral Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Cellular Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Cellular Process Peptidyl-lysine Modification Rhythmic Process Histone H3 Acetylation Chromatin Modification Metabolic Process Histone Modification Chromosome Organization Chromatin Organization Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		absent additionally allograft assayed class constitutively derepression fetal gamma histocompatibility ifn inducer lesion mhc neither preventing problem promoters rejection rfx suppression transactivator transfected transfection trophoblast trophoblasts vector x2bp	acting alternative choice cis comparative decisions define depletion dictate drives elements employ gain inducible microarray minigene modulate mutational nothing pivotal pol splice splicing taf6alpha taf6delta tfiid transcriptome triggering undefined
Tagcloud (Difference) ?		absent additionally allograft assayed class constitutively derepression fetal gamma histocompatibility ifn inducer lesion mhc neither preventing problem promoters rejection rfx suppression transactivator transfected transfection trophoblast trophoblasts vector x2bp	acting alternative choice cis comparative decisions define depletion dictate drives elements employ gain inducible microarray minigene modulate mutational nothing pivotal pol splice splicing taf6alpha taf6delta tfiid transcriptome triggering undefined
Tagcloud (Intersection) ?