CIITA and RFX5

Number of citations: 32 (PubMedID 9177217)
Data Source: HPRD (in vitro)

		CIITA	RFX5
Name		class II major histocompatibility complex transactivator	regulatory factor X5
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol PML Body	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Acyltransferase Activity Histone Deacetylase Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Immune Response Negative Regulation Of Collagen Biosynthetic Process Response To Type II Interferon Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Suppression Of Symbiont Invasion Response To Antibiotic Type II Interferon-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interferon gamma signaling	None
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2
GWAS		Alopecia areata ( 25608926 ) Asthma ( 31619474 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Celiac disease ( 20190752 22057235 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Nasopharyngeal carcinoma ( 27436580 ) Systemic lupus erythematosus ( 26502338 27399966 ) Ulcerative colitis ( 20228799 )	Body mass index ( 26426971 )
Interacting Genes		18 interacting genes: CDK1 CREBBP GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC	6 interacting genes: APP CFAP298 CIITA HDAC2 RFXANK RFXAP
Entrez ID		4261	5993
HPRD ID		02475	03517
Ensembl ID		ENSG00000179583	ENSG00000143390
Uniprot IDs		A0A087X2I7 P33076 Q66X48	P48382
PDB IDs		Not available	2KW3 3V30
GO Terms Enriched among Interactors		DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Organization Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process P53 Binding Transcription Coactivator Activity Protein-lysine-acetyltransferase Activity Nucleus Regulation Of Macromolecule Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Rhythmic Process Regulation Of Metabolic Process Histone Deacetylase Binding Regulation Of Generation Of Precursor Metabolites And Energy RNA Polymerase II Transcription Regulator Complex Protein Lysine Deacetylase Activity Chromatin Binding Transcription Preinitiation Complex Assembly Negative Regulation Of Myotube Differentiation Negative Regulation Of Macromolecule Metabolic Process Acetyltransferase Activity Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding SAGA Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Regulation Of DNA Repair Transcription Factor TFIID Complex Protein Acetylation	Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylase Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Dendrite Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Nucleus Positive Regulation Of Male Mating Behavior Positive Regulation Of Interleukin-1 Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Golgi Lumen Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Cell Projection Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway