CIITA and RFX5

Number of citations of the paper that reports this interaction (PMID 9177217)
31

Data Source:
HPRD (in vitro)

		CIITA	RFX5
Gene Name		class II, major histocompatibility complex, transactivator	regulatory factor X, 5 (influences HLA class II expression)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm PML Body	Nucleus
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Kinase Activity Transferase Activity, Transferring Acyl Groups Protein Complex Binding Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Immune Response Phosphorylation Cytokine-mediated Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Antibiotic Interferon-gamma-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Ulcerative colitis ( 20228799)
Protein-Protein Interactions		17 interactors: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC	5 interactors: ANKRA2 CIITA HDAC2 RFXANK RFXAP
Entrez ID		4261	5993
HPRD ID		02475	03517
Ensembl ID		ENSG00000179583	ENSG00000143390
Uniprot IDs		E9PFE0 P33076 Q66X48	B7Z848 P48382
PDB IDs			2KW3 3V30
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Histone Modification Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Chromatin Modification Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Peptidyl-amino Acid Modification Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Histone H4 Deacetylation Regulation Of Protein Export From Nucleus Peptidyl-lysine Modification Regulation Of Binding Histone Acetylation Transcription From RNA Polymerase II Promoter Internal Peptidyl-lysine Acetylation Viral Process Peptidyl-lysine Acetylation Negative Regulation Of Biosynthetic Process Internal Protein Amino Acid Acetylation Response To Organic Substance	Regulation Of Collagen Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Maintenance Of Chromatin Silencing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of MHC Class II Biosynthetic Process Fungiform Papilla Formation Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Fungiform Papilla Morphogenesis Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Regulation Of Sarcomere Organization Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Positive Regulation Of Oligodendrocyte Differentiation Tongue Morphogenesis Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Tissue Development Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Histone H3 Deacetylation Negative Regulation Of Organ Growth Tongue Development Positive Regulation Of Glial Cell Differentiation Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Regulation Of Oligodendrocyte Differentiation Regulation Of Cardiac Muscle Cell Proliferation RNA Biosynthetic Process Negative Regulation Of Striated Muscle Tissue Development Response To Cocaine
Tagcloud ?		absent additionally allograft assayed class constitutively derepression fetal gamma histocompatibility ifn inducer lesion mhc neither preventing problem promoters rejection rfx suppression transactivator transfected transfection trophoblast trophoblasts vector x2bp	bind box boxes conserved contributions cus dictate dra effectors entire flanking functionally herpes heterodimer histocompatibility homodimer p36 plasmid proper rfx1 simplex spacing stabilized upstream vp16 x2 y
Tagcloud (Difference) ?		absent additionally allograft assayed class constitutively derepression fetal gamma ifn inducer lesion mhc neither preventing problem promoters rejection suppression transactivator transfected transfection trophoblast trophoblasts vector x2bp	bind box boxes conserved contributions cus dictate dra effectors entire flanking functionally herpes heterodimer homodimer p36 plasmid proper rfx1 simplex spacing stabilized upstream vp16 x2 y
Tagcloud (Intersection) ?		histocompatibility rfx