MGST2 and PNKP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MGST2	PNKP
Description		microsomal glutathione S-transferase 2	polynucleotide kinase 3'-phosphatase
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GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Chromosome Nucleolus Membrane Site Of Double-strand Break
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Oxidoreductase Activity Transferase Activity Lyase Activity Identical Protein Binding Glutathione Binding	Nucleotide Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity Endonuclease Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Lipid Metabolic Process Leukotriene Metabolic Process Glutathione Biosynthetic Process Leukotriene Biosynthetic Process Response To Lipopolysaccharide Carboxylic Acid Biosynthetic Process Membrane Lipid Catabolic Process Positive Regulation Of Inflammatory Response Cellular Oxidant Detoxification	DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To Oxidative Stress Response To Radiation Positive Regulation Of Telomere Maintenance Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Glutathione conjugation Aflatoxin activation and detoxification	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs		Glutathione
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: ASIC1 BCL2L10 BCL2L2 C3orf52 CCL3L3 CLEC14A CREB3 CREB3L1 CTXN3 DNAJC30 GIMAP5 GJA8 GPX8 HDHD2 PLN PNKP SEC22A SEC22B SGCB STX8 TMEM167B TMEM207 VAMP3	50 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CISD2 CNTROB COL17A1 DRC4 DVL3 EIF4ENIF1 FADS6 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 OGT PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		4258	11284
HPRD ID		03436	09284
Ensembl ID		ENSG00000085871	ENSG00000039650
Uniprot IDs		Q99735	Q96T60
PDB IDs		6SSR 6SSS 6SSU 6SSW	2BRF 2W3O
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity Membrane Membrane Fusion	Regulation Of Long-term Neuronal Synaptic Plasticity Protein Binding Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Synaptic Vesicle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Enzyme Binding Base-excision Repair Immunoglobulin V(D)J Recombination Regulation Of Synaptic Plasticity Regulation Of Transcription By Glucose Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Regulation Of Synaptic Vesicle Priming Negative Regulation Of Biosynthetic Process Protein Monoubiquitination Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Double-strand Break Repair Via Nonhomologous End Joining
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