MGST2 and HDHD2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		MGST2	HDHD2
Gene Name		microsomal glutathione S-transferase 2	haloacid dehalogenase-like hydrolase domain containing 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Extracellular Vesicular Exosome
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Enzyme Activator Activity	Enzyme Binding Metal Ion Binding
	Biological Process	Glutathione Biosynthetic Process Xenobiotic Metabolic Process Response To Organonitrogen Compound Leukotriene Biosynthetic Process Response To Lipopolysaccharide Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Oxidation-reduction Process Glutathione Derivative Biosynthetic Process	Biological_process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Aflatoxin activation and detoxification Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective ACY1 causes encephalopathy Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: HDHD2	12 interactors: BAI2 CFD CRMP1 DVL1 EPHB6 LUC7L2 MEOX2 MGST2 PIP5K1C SOD2 TARBP2 TRAPPC11
Entrez ID		4258	84064
HPRD ID		03436	13640
Ensembl ID		ENSG00000085871	ENSG00000167220
Uniprot IDs		Q99735	Q9H0R4
PDB IDs			3HLT
Enriched GO Terms of Interacting Partners?			Axon Guidance Neuron Development Axonogenesis Response To External Stimulus Axon Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Nervous System Development Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Neuron Projection Development Glutathione Metabolic Process Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Cell Development Neurotransmitter Secretion Cell Morphogenesis Convergent Extension Involved In Neural Plate Elongation Targeting Of MRNA For Destruction Involved In RNA Interference Response To Silicon Dioxide Response To Magnetism System Development Secretion By Cell Cell Projection Organization Regulation Of Neurotransmitter Levels Collateral Sprouting Age-dependent Response To Oxidative Stress Production Of SiRNA Involved In RNA Interference Detection Of Oxygen Peptide Metabolic Process Locomotion Convergent Extension Involved In Organogenesis Somite Specification Response To Selenium Ion Ribonucleoprotein Complex Assembly Neurotransmitter Transport Secretion Multicellular Organismal Development Oxygen Homeostasis Pyrimidine Nucleobase Catabolic Process Protein Localization To Microtubule Platelet Activation RNA Interference
Tagcloud ?		2a ark axl believed biosynthesis cataract chaperones contributor defense downregulated glutathione groundwork hle hour hsp40 lens microarrays orp150 os peroxiredoxin perspective reductase respond return rnas subcategories thioredoxin trafficking transferase
Tagcloud (Difference) ?		2a ark axl believed biosynthesis cataract chaperones contributor defense downregulated glutathione groundwork hle hour hsp40 lens microarrays orp150 os peroxiredoxin perspective reductase respond return rnas subcategories thioredoxin trafficking transferase
Tagcloud (Intersection) ?