MGST2 and CCL3L3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MGST2	CCL3L3
Description		microsomal glutathione S-transferase 2	C-C motif chemokine ligand 3 like 3
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Oxidoreductase Activity Transferase Activity Lyase Activity Identical Protein Binding Glutathione Binding	Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Lipid Metabolic Process Leukotriene Metabolic Process Glutathione Biosynthetic Process Leukotriene Biosynthetic Process Response To Lipopolysaccharide Carboxylic Acid Biosynthetic Process Membrane Lipid Catabolic Process Positive Regulation Of Inflammatory Response Cellular Oxidant Detoxification	Chemotaxis Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Glutathione conjugation Aflatoxin activation and detoxification	Chemokine receptors bind chemokines Interleukin-10 signaling
Drugs		Glutathione
Diseases
GWAS		Metabolite levels ( 23823483)	Body mass index ( 26426971)
Interacting Genes		23 interacting genes: ASIC1 BCL2L10 BCL2L2 C3orf52 CCL3L3 CLEC14A CREB3 CREB3L1 CTXN3 DNAJC30 GIMAP5 GJA8 GPX8 HDHD2 PLN PNKP SEC22A SEC22B SGCB STX8 TMEM167B TMEM207 VAMP3	6 interacting genes: ACKR2 CCR5 MGST2 SGTB SLC41A3 TMEM179B
Entrez ID		4258	414062
HPRD ID		03436	14426
Ensembl ID		ENSG00000085871	ENSG00000276085
Uniprot IDs		Q99735	P16619
PDB IDs		6SSR 6SSS 6SSU 6SSW
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity Membrane Membrane Fusion	Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding TRC Complex Mitochondrial Magnesium Ion Transmembrane Transport Magnesium:sodium Antiporter Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Decoy Activity Calcium-mediated Signaling Leukotriene-C4 Synthase Activity Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Locomotion Dendritic Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Macrophage Apoptotic Process External Side Of Plasma Membrane Plasma Membrane Chemotaxis Membrane Glutathione Biosynthetic Process Glutathione Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Monoatomic Cation Transmembrane Transporter Activity Leukotriene Biosynthetic Process G Protein-coupled Receptor Activity Negative Regulation Of Myeloid Cell Apoptotic Process Glutathione Peroxidase Activity Cytokine-mediated Signaling Pathway Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Peptide Biosynthetic Process Response To Cholesterol Protein Heterooligomerization Glutathione Transferase Activity Protein Targeting To ER Leukotriene Metabolic Process Regulation Of Myeloid Cell Apoptotic Process Establishment Of Protein Localization To Endoplasmic Reticulum
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