MFAP1 and MAD1L1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MFAP1	MAD1L1
Gene Name		microfibrillar-associated protein 1	MAD1 mitotic arrest deficient-like 1 (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region	Kinetochore Condensed Chromosome Kinetochore Nucleus Nuclear Pore Cytoplasm Centrosome Spindle Cytosol Actin Cytoskeleton Mitotic Spindle
	Molecular Function	Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Biological_process Extracellular Matrix Organization	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Regulation Of Metaphase Plate Congression
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cell Cycle Checkpoints Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Longevity ( 20834067) Schizophrenia ( 22688191) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		47 interactors: AES AMOTL2 BEND7 CARD9 CCDC57 CDCA7L CEP55 CEP57L1 CEP70 COIL CSNK2A1 DHX38 DHX8 FAM9B FRA10AC1 FXR2 GKAP1 GOLGA2 HMBOX1 HSPB1 IK KATNBL1 KIFC3 KRT40 LDOC1 MAD1L1 MID2 MIPOL1 MTUS2 NDC80 PHC2 SART1 SMU1 SNIP1 SNW1 SSX2IP STX11 TADA2A TRIM42 TRIM54 U2AF1 VPS52 YWHAG ZBTB14 ZBTB8A ZFP64 ZNF398	38 interactors: ALOX5 AMOTL2 BAG5 CCDC94 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PSMA1 RNF8 SIN3A SIN3B SPATA2 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 ZSCAN32
Entrez ID		4236	8379
HPRD ID		02569	04065
Ensembl ID		ENSG00000140259	ENSG00000002822
Uniprot IDs		P55081	B3KR41 Q9Y6D9
PDB IDs			1GO4 4DZO
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Mitotic Cell Cycle Process Transcription, DNA-templated RNA Biosynthetic Process Cell Cycle Process Cell Cycle RNA Splicing RNA Processing Regulation Of Chromosome Organization Regulation Of Tumor Necrosis Factor Biosynthetic Process MRNA Processing Negative Regulation Of Cellular Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Metabolic Process Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Splicing Termination Of RNA Polymerase II Transcription Maturation Of 5S RRNA Regulation Of Metaphase Plate Congression Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Organelle Organization Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Anchoring Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Cytotoxic T Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Embryonic Ectodermal Digestive Tract Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Tumor Necrosis Factor Production Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Zonula Adherens Maintenance Microtubule-based Process MRNA Export From Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Negative Regulation Of Gene Expression Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Organelle Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Histone Deacetylation Protein Deacetylation Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Process Histone Modification Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Chromatin Modification Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter G2/M Transition Of Mitotic Cell Cycle Cell Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Regulation Of Cell Cycle Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Spindle Checkpoint Transcription, DNA-templated Positive Regulation Of Cell Cycle Chromatin Organization
Tagcloud ?			adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Difference) ?			adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Intersection) ?