MFAP1 and ALKBH8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MFAP1	ALKBH8
Description		microfibril associated protein 1	alkB homolog 8, tRNA methyltransferase
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GO Annotations	Cellular Component	Microfibril Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex Centrosome U2-type Precatalytic Spliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding	TRNA Binding Nucleic Acid Binding RNA Binding Catalytic Activity Iron Ion Binding Protein Binding Methyltransferase Activity Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity TRNA (uridine) Methyltransferase Activity 2-oxoglutarate-dependent Dioxygenase Activity Transferase Activity Metal Ion Binding Transition Metal Ion Binding TRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	TRNA Wobble Uridine Modification DNA Damage Response TRNA Methylation Methylation
Pathways		mRNA Splicing - Major Pathway	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Large artery stroke ( 24262325)
Interacting Genes		88 interacting genes: ALKBH8 AMOTL2 AP2M1 BEND7 BICD2 CARD9 CCDC102B CCDC33 CCDC57 CDC14B CDCA7L CEP55 CEP57L1 CEP70 CEP76 COG6 CSNK2A1 DHX38 DHX8 DNTTIP1 DRC4 FAM9B FRA10AC1 FXR1 FXR2 GKAP1 GOLGA2 GOLGA6L9 GPRASP3 GRIPAP1 HMBOX1 HOMER3 HOOK2 HSF2BP HSPB1 IK KATNBL1 KIFC3 KLHL2 KRT40 L3MBTL3 LDOC1 LMNA LMNB2 LZTS1 MAD1L1 MCRS1 MID2 MIPOL1 MTUS2 NDC80 NGDN OGT OLIG3 PAX6 PHC2 PIBF1 PIH1D1 PLEKHF2 SNW1 SSX2IP STAC3 STX11 TADA2A TCP10L TEPSIN TFIP11 THAP1 TLE5 TRAF2 TRIM41 TRIM42 TRIM54 U2AF1 VPS52 YWHAG ZBTB1 ZBTB14 ZBTB8A ZFP1 ZFP41 ZFP64 ZNF398 ZNF41 ZNF558 ZNF620 ZNF71 ZNF76	3 interacting genes: APP MFAP1 PICK1
Entrez ID		4236	91801
HPRD ID		02569	14287
Ensembl ID		ENSG00000140259	ENSG00000137760
Uniprot IDs		P55081	Q96BT7
PDB IDs		5F5S 5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9 8QPE 8QZS	2CQ2 3THP 3THT
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Nucleus Microtubule Binding Cytoskeleton Centrosome Nuclear Pore Localization Zinc Ion Binding Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization TORC1 Complex Assembly MRNA Splicing, Via Spliceosome Protein Kinase C Inhibitor Activity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Catalytic Step 2 Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Spindle Pole Response To Muramyl Dipeptide Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Spliceosomal Complex Microtubule Negative Regulation Of Metabolic Process Intracellular Protein Localization Cytoskeleton Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Macromolecule Metabolic Process Membraneless Organelle Assembly Regulation Of Chromosome Separation Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Negative Regulation Of Chromosome Organization Chromosome Localization Negative Regulation Of Macromolecule Metabolic Process ATP-dependent Activity, Acting On RNA Mitotic Spindle Pole Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Mitotic Nuclear Division Cellular Response To Muramyl Dipeptide Nucleus Organization Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint NSL Complex	Positive Regulation Of Receptor Internalization Neuron Projection Organization Positive Regulation Of Receptor-mediated Endocytosis G Protein-coupled Receptor Binding Regulation Of Receptor Internalization Glial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Trans-Golgi Network Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Receptor-mediated Endocytosis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synaptic Plasticity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Membrane Curvature Sensor Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Endocytosis Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neuron Projection Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Negative Regulation Of Actin Nucleation Regulation Of Supramolecular Fiber Organization
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