MFAP1 and HMBOX1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		MFAP1	HMBOX1
Description		microfibril associated protein 1	homeobox containing 1
Image
GO Annotations	Cellular Component	Microfibril Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex Centrosome U2-type Precatalytic Spliceosome	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cajal Body Nuclear Body PML Body
	Molecular Function	RNA Binding Protein Binding	DNA Binding Double-stranded Telomeric DNA Binding Protein Binding Telomeric DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Telomerase Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Telomere-telomerase Complex Assembly
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)	Obesity-related traits ( 23251661)
Interacting Genes		88 interacting genes: ALKBH8 AMOTL2 AP2M1 BEND7 BICD2 CARD9 CCDC102B CCDC33 CCDC57 CDC14B CDCA7L CEP55 CEP57L1 CEP70 CEP76 COG6 CSNK2A1 DHX38 DHX8 DNTTIP1 DRC4 FAM9B FRA10AC1 FXR1 FXR2 GKAP1 GOLGA2 GOLGA6L9 GPRASP3 GRIPAP1 HMBOX1 HOMER3 HOOK2 HSF2BP HSPB1 IK KATNBL1 KIFC3 KLHL2 KRT40 L3MBTL3 LDOC1 LMNA LMNB2 LZTS1 MAD1L1 MCRS1 MID2 MIPOL1 MTUS2 NDC80 NGDN OGT OLIG3 PAX6 PHC2 PIBF1 PIH1D1 PLEKHF2 SNW1 SSX2IP STAC3 STX11 TADA2A TCP10L TEPSIN TFIP11 THAP1 TLE5 TRAF2 TRIM41 TRIM42 TRIM54 U2AF1 VPS52 YWHAG ZBTB1 ZBTB14 ZBTB8A ZFP1 ZFP41 ZFP64 ZNF398 ZNF41 ZNF558 ZNF620 ZNF71 ZNF76	98 interacting genes: ABITRAM AEBP2 ANKRD36 APP ATP5PO BAZ2B BEND7 BRD1 BYSL C8orf33 CARD9 CBX8 CCDC187 CCNG1 CDC7 CDCA8 CDK18 DAB1 DNTTIP1 DYNLL1 ENKD1 ENTPD2 FAM13C FAM161A FAM217B FAM74A4 FAM90A1 FARS2 FGF11 FNDC11 FRMD6 FXR2 GAS2L2 GNL3L GSC2 INO80B IPO13 KAT5 KIF9 LMO1 LMO3 LNX1 MAGEH1 MCRS1 MEOX1 MEOX2 MFAP1 MORF4L1 MORF4L2 MRPL11 MRPL28 PAX5 PAX6 PIAS2 PICK1 PIP4K2B PKD1P1 POLDIP3 POLL PRKAA1 PRKAA2 PRPF18 RBMY2FP RCOR3 REEP6 RPL9 RPS25 SAP30L SCNM1 SDCBP SFR1 SH2D4A SNRPB2 SNW1 SYT6 TBP TCEA2 TCEANC TSGA10IP TUFM U2AF2 UBA6 UBE2I UBE2Z VAX1 VPS72 WT1 ZBTB24 ZBTB26 ZFYVE26 ZMAT2 ZMYM5 ZNF250 ZNF337 ZNF417 ZNF581 ZNF587 ZNF688
Entrez ID		4236	79618
HPRD ID		02569	07964
Ensembl ID		ENSG00000140259	ENSG00000147421
Uniprot IDs		P55081	Q6NT76
PDB IDs		5F5S 5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9 8QPE 8QZS	2CUF 4J19
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Nucleus Microtubule Binding Cytoskeleton Centrosome Nuclear Pore Localization Zinc Ion Binding Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization TORC1 Complex Assembly MRNA Splicing, Via Spliceosome Protein Kinase C Inhibitor Activity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Catalytic Step 2 Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Spindle Pole Response To Muramyl Dipeptide Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Spliceosomal Complex Microtubule Negative Regulation Of Metabolic Process Intracellular Protein Localization Cytoskeleton Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Macromolecule Metabolic Process Membraneless Organelle Assembly Regulation Of Chromosome Separation Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Negative Regulation Of Chromosome Organization Chromosome Localization Negative Regulation Of Macromolecule Metabolic Process ATP-dependent Activity, Acting On RNA Mitotic Spindle Pole Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Mitotic Nuclear Division Cellular Response To Muramyl Dipeptide Nucleus Organization Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint NSL Complex	Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Speck Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Lipid Droplet Disassembly Protein Binding Positive Regulation Of DNA Repair NuA4 Histone Acetyltransferase Complex Regulation Of Macromolecule Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process DNA Recombination Chromatin Organization Spliceosomal Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Glucose Starvation Protein Localization To Lipid Droplet Positive Regulation Of DNA Metabolic Process Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Somite Specification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Phosphatidylethanolamine Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Regulation Of Tubulin Deacetylation Astrocyte Differentiation
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