MFAP1 and DHX38

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		MFAP1	DHX38
Gene Name		microfibrillar-associated protein 1	DEAH (Asp-Glu-Ala-His) box polypeptide 38
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region	Nucleus Nucleoplasm Cytoplasm Membrane Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Biological_process Extracellular Matrix Organization	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing
Pathways		Molecules associated with elastic fibres Elastic fibre formation	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Metabolite levels ( 22916037)
Protein-Protein Interactions		47 interactors: AES AMOTL2 BEND7 CARD9 CCDC57 CDCA7L CEP55 CEP57L1 CEP70 COIL CSNK2A1 DHX38 DHX8 FAM9B FRA10AC1 FXR2 GKAP1 GOLGA2 HMBOX1 HSPB1 IK KATNBL1 KIFC3 KRT40 LDOC1 MAD1L1 MID2 MIPOL1 MTUS2 NDC80 PHC2 SART1 SMU1 SNIP1 SNW1 SSX2IP STX11 TADA2A TRIM42 TRIM54 U2AF1 VPS52 YWHAG ZBTB14 ZBTB8A ZFP64 ZNF398	6 interactors: CDC40 CSNK2A1 MFAP1 PPP4C TERF2IP U2AF1
Entrez ID		4236	9785
HPRD ID		02569	05720
Ensembl ID		ENSG00000140259	ENSG00000140829
Uniprot IDs		P55081	Q92620
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Mitotic Cell Cycle Process Transcription, DNA-templated RNA Biosynthetic Process Cell Cycle Process Cell Cycle RNA Splicing RNA Processing Regulation Of Chromosome Organization Regulation Of Tumor Necrosis Factor Biosynthetic Process MRNA Processing Negative Regulation Of Cellular Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Metabolic Process Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Splicing Termination Of RNA Polymerase II Transcription Maturation Of 5S RRNA Regulation Of Metaphase Plate Congression Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Organelle Organization Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Anchoring Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Cytotoxic T Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Embryonic Ectodermal Digestive Tract Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Tumor Necrosis Factor Production Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Zonula Adherens Maintenance Microtubule-based Process MRNA Export From Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Termination Of RNA Polymerase II Transcription Regulation Of DNA Repair MRNA Export From Nucleus Regulation Of DNA Recombination DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere RNA 3'-end Processing Nuclear Export MRNA Transport Regulation Of Response To DNA Damage Stimulus RNA Transport RNA Localization Regulation Of Chromosome Organization Transcription, DNA-templated Protection From Non-homologous End Joining At Telomere RNA Biosynthetic Process MRNA Splicing, Via Spliceosome Telomere Capping Protein Localization To Chromosome, Telomeric Region RNA Splicing, Via Transesterification Reactions Nucleocytoplasmic Transport Nuclear Transport Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance RNA Splicing RNA Metabolic Process MRNA Processing Regulation Of Telomere Maintenance Gene Expression RNA-dependent DNA Replication Negative Regulation Of DNA Recombination Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Metabolic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening RNA Processing Mitotic Spindle Checkpoint NIK/NF-kappaB Signaling Negative Regulation Of Chromosome Segregation Cytoplasmic Transport Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition
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