EIF4EBP1 and RHEBL1

Number of citations of the paper that reports this interaction (PMID 16098514)
27

Data Source:
HPRD (in vivo)

		EIF4EBP1	RHEBL1
Gene Name		eukaryotic translation initiation factor 4E binding protein 1	Ras homolog enriched in brain like 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein Complex	Cytoplasm Endomembrane System Membrane
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity	GTP Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle IRES-dependent Translational Initiation Response To Ischemia Translation Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Lung Development Negative Regulation Of Protein Complex Assembly TOR Signaling Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation	Small GTPase Mediated Signal Transduction TOR Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		IRS-mediated signalling mTOR signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Release of eIF4E Eukaryotic Translation Initiation PKB-mediated events Cap-dependent Translation Initiation PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Translation IRS-related events Release of eIF4E mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 EIF4E EIF4E2 GSK3B IRAK4 LATS1 LRRK2 MAPK1 MAPK14 MAPKAP1 MAPKAPK5 MLST8 MTOR MVD PPP2CA PPP2R4 PRKCA PRKDC REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4	13 interactors: ACVR1 AKT1 APPL1 BMPR1B EIF4EBP1 FHL3 MTOR PRKAB2 SMAD1 SMAD2 SMAD4 TGFBR1 TXNL4A
Entrez ID		1978	121268
HPRD ID		03746	15245
Ensembl ID		ENSG00000187840	ENSG00000167550
Uniprot IDs		Q13541	Q8TAI7
PDB IDs		1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X	3OES
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Phosphorylation Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Cell Cycle Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Cycle Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Cellular Protein Modification Process Regulation Of Protein Phosphorylation Cell Communication Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Heat Regulation Of Cellular Response To Heat Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Protein Metabolic Process Response To Growth Factor Negative Regulation Of Cellular Protein Metabolic Process Innate Immune Response Cell Death	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Organic Substance Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta SMAD Protein Complex Assembly Response To Organic Substance Intracellular Signal Transduction Cellular Response To Insulin Stimulus BMP Signaling Pathway Protein Phosphorylation Pattern Specification Process Positive Regulation Of Cell Differentiation Cell Fate Commitment Cellular Response To Hormone Stimulus Response To Insulin Regulation Of Cell Differentiation Activin Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Gamete Generation Cellular Response To Peptide Mesoderm Development Urogenital System Development Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Sexual Reproduction Peptidyl-threonine Phosphorylation Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Reproductive Process Gastrulation Response To Organonitrogen Compound Regulation Of Epithelial To Mesenchymal Transition Cell Cycle Multicellular Organism Reproduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Signal Transduction Cardiovascular System Development Mesenchyme Development Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Organonitrogen Compound Organ Development
Tagcloud ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley	aspartate binds cad carbamoyl consist de dihydroorotase effector farnesyltransferase gtp gtpases immunostaining knocking lysosomes mislocalized multifunctional novo nucleotides phosphate pronounced pyrimidine rheb2 superfamily synthetase transcarbamoylase tsc2 utp
Tagcloud (Difference) ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley	aspartate binds cad carbamoyl consist de dihydroorotase effector farnesyltransferase gtp gtpases immunostaining knocking lysosomes mislocalized multifunctional novo nucleotides phosphate pronounced pyrimidine rheb2 superfamily synthetase transcarbamoylase tsc2 utp
Tagcloud (Intersection) ?