EIF4EBP1 and RPS6KA5

Number of citations: 0 (PubMedID 11777913)
Data Source: HPRD (in vitro)

		EIF4EBP1	RPS6KA5
Name		eukaryotic translation initiation factor 4E binding protein 1	ribosomal protein S6 kinase A5
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Translation Initiation Factor Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Histone H2AS1 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Translation Negative Regulation Of Translation TOR Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Axon Guidance Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Regulation Of Postsynapse Organization
Pathways		mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
GWAS		Menopause (age at onset) ( 29773799 )	A body shape index ( 34021172 ) Adult body size ( 32376654 ) Bitter alcoholic beverage consumption ( 31046077 ) Femoral neck bone mineral density ( 22504420 29499414 ) Fractures ( 30158200 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lumbar spine bone mineral density ( 29499414 ) Multiple sclerosis ( 31604244 ) Proportion of activated microglia (inferior temporal cortex) ( 30679421 ) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		38 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD PICK1 POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655	60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CRYAA CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AC25 H2BC21 H2BC26 H2BC3 H3-4 H3C14 H3C6 H4C14 H4C16 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775
Entrez ID		1978	9252
HPRD ID		03746	06789
Ensembl ID		ENSG00000187840	ENSG00000100784
Uniprot IDs		Q13541	O75582
PDB IDs		1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX 8RCH 8RCK 8RCN	1VZO 3KN5 3KN6 7UP4 7UP5 7UP6 7UP7 7UP8
GO Terms Enriched among Interactors		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Phosphorylation ATP Binding Phosphorylation TOR Signaling Nucleotide Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Intracellular Signaling Cassette Negative Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Translation Regulation Of Gene Expression TORC2 Signaling Positive Regulation Of Cellular Component Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Growth Regulation Of Signal Transduction Post-transcriptional Regulation Of Gene Expression Regulation Of Autophagy Negative Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Cycle Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Transferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Positive Regulation Of Growth Cellular Response To Nutrient Levels TORC1 Signaling Response To Nutrient Levels Protein Metabolic Process Regulation Of TORC2 Signaling Positive Regulation Of Protein-containing Complex Assembly	Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Chromatin Organization DNA Binding Response To Light Stimulus Protein Heterodimerization Activity Response To UV Response To UV-B Nucleosome Assembly Nucleus Chromatin Remodeling Protein-containing Complex Assembly Chromatin DNA Binding Protein-containing Complex Organization Protein-DNA Complex Assembly Regulation Of Cell Development Response To Radiation Chromatin Cellular Response To UV Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Cellular Response To UV-B Regulation Of Cell Differentiation Transcription Regulator Complex Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Nucleoplasm Double-stranded DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Chromosome Cellular Component Assembly Chromatin Binding Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Regulation Of Myeloid Cell Differentiation Transcription Coactivator Binding Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Intracellular Signal Transduction