EIF4EBP1 and CHTF8

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF4EBP1	CHTF8
Description		eukaryotic translation initiation factor 4E binding protein 1	chromosome transmission fidelity factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Ctf18 RFC-like Complex
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Translation Initiation Factor Binding	DNA Binding DNA Clamp Loader Activity Protein Binding Single-stranded DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Translation Negative Regulation Of Translation TOR Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation	DNA Replication Mitotic Sister Chromatid Cohesion Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Polymerase switching on the C-strand of the telomere
Drugs
Diseases
GWAS		Menopause (age at onset) ( 29773799)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		38 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD PICK1 POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655	6 interacting genes: AP4M1 DSCC1 EIF4EBP1 PCNA RFC3 WBP4
Entrez ID		1978	54921
HPRD ID		03746	16797
Ensembl ID		ENSG00000187840	ENSG00000168802
Uniprot IDs		Q13541	P0CG13
PDB IDs		1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX 8RCH 8RCK 8RCN
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Phosphorylation ATP Binding Phosphorylation TOR Signaling Nucleotide Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Intracellular Signaling Cassette Negative Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Translation Regulation Of Gene Expression TORC2 Signaling Positive Regulation Of Cellular Component Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Growth Regulation Of Signal Transduction Post-transcriptional Regulation Of Gene Expression Regulation Of Autophagy Negative Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Cycle Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Transferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Positive Regulation Of Growth Cellular Response To Nutrient Levels TORC1 Signaling Response To Nutrient Levels Protein Metabolic Process Regulation Of TORC2 Signaling Positive Regulation Of Protein-containing Complex Assembly	Positive Regulation Of DNA-directed DNA Polymerase Activity Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex DNA Clamp Loader Activity DNA Strand Elongation Involved In DNA Replication DNA Replication DNA Strand Elongation Single-stranded DNA Helicase Activity DNA Synthesis Involved In DNA Repair Positive Regulation Of DNA Metabolic Process Positive Regulation Of Catalytic Activity PCNA Complex Replisome DNA Biosynthetic Process Regulation Of DNA Metabolic Process PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Regulation Of Catalytic Activity Regulation Of DNA Replication Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Protein Localization To Basolateral Plasma Membrane Post-translational Protein Acetylation Positive Regulation Of Deoxyribonuclease Activity DNA Metabolic Process Leading Strand Elongation AP-4 Adaptor Complex Maintenance Of Mitotic Sister Chromatid Cohesion DNA Replication Factor C Complex MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Nucleic Acid Metabolic Process Eukaryotic Initiation Factor 4E Binding Estrous Cycle Golgi To Lysosome Transport Clathrin Adaptor Complex Nuclear Lamina Base-excision Repair, Gap-filling Golgi To Endosome Transport Translation Repressor Activity Nucleobase-containing Compound Metabolic Process Chromosome Organization MRNA Cis Splicing, Via Spliceosome Nuclear Replication Fork Response To L-glutamate Ovulation Cycle Golgi To Vacuole Transport Precatalytic Spliceosome
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