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EIF4EBP1 and CHTF8
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
EIF4EBP1
CHTF8
Gene Name
eukaryotic translation initiation factor 4E binding protein 1
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Protein Complex
Nucleus
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Eukaryotic Initiation Factor 4E Binding
Translation Repressor Activity
DNA Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
IRES-dependent Translational Initiation
Response To Ischemia
Translation
Translational Initiation
Insulin Receptor Signaling Pathway
Gene Expression
Lung Development
Negative Regulation Of Protein Complex Assembly
TOR Signaling
Cellular Protein Metabolic Process
Response To Ethanol
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of Translational Initiation
DNA Replication
Cell Cycle
Pathways
IRS-mediated signalling
mTOR signalling
mTOR signalling
mTORC1-mediated signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Release of eIF4E
Eukaryotic Translation Initiation
PKB-mediated events
Cap-dependent Translation Initiation
PI3K Cascade
Signaling by Insulin receptor
Insulin receptor signalling cascade
Translation
IRS-related events
Release of eIF4E
mTORC1-mediated signalling
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
PKB-mediated events
PI3K Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions
32 interactors:
AKT1
ATM
BUB1
CHTF8
CSNK2A1
CSNK2A2
EIF4E
EIF4E2
GSK3B
IRAK4
LATS1
LRRK2
MAPK1
MAPK14
MAPKAP1
MAPKAPK5
MLST8
MTOR
MVD
PPP2CA
PPP2R4
PRKCA
PRKDC
REL
RHEBL1
RICTOR
RORC
RPS6KA5
RPS6KB1
RPTOR
STK3
TCF4
6 interactors:
AP4M1
DSCC1
EIF4EBP1
PCNA
RFC3
WBP4
Entrez ID
1978
54921
HPRD ID
03746
16797
Ensembl ID
ENSG00000187840
ENSG00000168802
Uniprot IDs
Q13541
P0CG13
PDB IDs
1WKW
2JGB
2JGC
2V8W
2V8X
2V8Y
3HXG
3HXI
3M93
3M94
3U7X
Enriched GO Terms of Interacting Partners
?
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Peptidyl-serine Phosphorylation
Protein Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Phosphorylation
Phosphorylation
Positive Regulation Of Protein Modification Process
Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Cell Cycle
Cellular Response To Organic Substance
Response To Organic Substance
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Signaling
Cell Cycle Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Phosphorylation
Cellular Protein Modification Process
Regulation Of Protein Phosphorylation
Cell Communication
Phosphate-containing Compound Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Neurotrophin Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Signaling
Regulation Of Phosphorus Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Phosphorylation
Response To Heat
Regulation Of Cellular Response To Heat
Cellular Response To Fibroblast Growth Factor Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Response To Fibroblast Growth Factor
Positive Regulation Of Metabolic Process
Cellular Response To Growth Factor Stimulus
Protein Metabolic Process
Response To Growth Factor
Negative Regulation Of Cellular Protein Metabolic Process
Innate Immune Response
Cell Death
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Cell Cycle
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
DNA Replication
Transcription-coupled Nucleotide-excision Repair
Cell Cycle Process
Cell Cycle
Telomere Maintenance
Nucleotide-excision Repair
Positive Regulation Of Deoxyribonuclease Activity
DNA-dependent DNA Replication
DNA Biosynthetic Process
Regulation Of DNA Replication
Mitotic Cell Cycle Process
Leading Strand Elongation
G1/S Transition Of Mitotic Cell Cycle
Post-translational Protein Acetylation
Maintenance Of Mitotic Sister Chromatid Cohesion
IRES-dependent Translational Initiation
Cap-independent Translational Initiation
DNA Recombination
Chromosome Organization
DNA Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cytoplasmic Translational Initiation
Translesion Synthesis
Mitotic Sister Chromatid Cohesion
Cytoplasmic Translation
DNA Synthesis Involved In DNA Repair
MRNA Cis Splicing, Via Spliceosome
Golgi To Endosome Transport
Negative Regulation Of Translational Initiation
Postreplication Repair
TOR Signaling
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Sister Chromatid Cohesion
Response To Ischemia
DNA Repair
Cellular Homeostasis
Positive Regulation Of Nuclease Activity
Nucleobase-containing Compound Metabolic Process
Tagcloud
?
autophagy
bcl2
birc5
buffer
constituents
damaged
dataset
degrades
deregulation
distant
ero1l
fos
gapdh
gse21653
gse3494
gse7390
inc
itpr1
lived
organelles
periodicals
prognostic
proportional
shortened
signature
starvation
subgroups
vegfa
wiley
Tagcloud (Difference)
?
autophagy
bcl2
birc5
buffer
constituents
damaged
dataset
degrades
deregulation
distant
ero1l
fos
gapdh
gse21653
gse3494
gse7390
inc
itpr1
lived
organelles
periodicals
prognostic
proportional
shortened
signature
starvation
subgroups
vegfa
wiley
Tagcloud (Intersection)
?