EIF4EBP1 and EIF4E

Number of citations of the paper that reports this interaction (PubMedID 16648488)
51

Data Source:
HPRD (in vitro, in vivo)

		EIF4EBP1	EIF4E
Description		eukaryotic translation initiation factor 4E binding protein 1	eukaryotic translation initiation factor 4E
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Nuclear Body Nuclear Speck Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Translation Initiation Factor Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding MRNA Cap Binding DNA-binding Transcription Factor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Translation Negative Regulation Of Translation TOR Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response MRNA Export From Nucleus Translation Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle MRNA Transport Nuclear Export Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission
Pathways		mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs			7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Menopause (age at onset) ( 29773799)	Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol dependence ( 33290381) Daytime sleep phenotypes ( 27126917) HDL cholesterol levels ( 32203549) Mean arterial pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Menopause (age at onset) ( 29773799) Sensation seeking ( 30718321)
Interacting Genes		38 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD PICK1 POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655	38 interacting genes: ACVRL1 APP BIRC2 CD83 CEBPA CPEB1 CYFIP1 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 EN2 GEMIN5 HOXA9 IPO8 KANK2 LRPPRC MAPKAPK5 MKNK1 MKNK2 OTX2 PML PRDM4 PRKCA PRKCB PRKCG PTEN RNMT TDO2 TLX1 TRIM27 UBXN11 XPO1
Entrez ID		1978	1977
HPRD ID		03746	00591
Ensembl ID		ENSG00000187840	ENSG00000151247
Uniprot IDs		Q13541	D6RBW1 P06730 Q32Q75 X5D7E3
PDB IDs		1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX 8RCH 8RCK 8RCN	1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML 7D6Y 7D8B 7EZW 7F07 7MEU 7XTP 8QM4 8QM5 8QM6 8QM7 8QM8 8QM9 8SX4 9DON
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Phosphorylation ATP Binding Phosphorylation TOR Signaling Nucleotide Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Intracellular Signaling Cassette Negative Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Translation Regulation Of Gene Expression TORC2 Signaling Positive Regulation Of Cellular Component Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Growth Regulation Of Signal Transduction Post-transcriptional Regulation Of Gene Expression Regulation Of Autophagy Negative Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Cycle Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Transferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Positive Regulation Of Growth Cellular Response To Nutrient Levels TORC1 Signaling Response To Nutrient Levels Protein Metabolic Process Regulation Of TORC2 Signaling Positive Regulation Of Protein-containing Complex Assembly	Regulation Of Translation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Eukaryotic Initiation Factor 4E Binding Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Translational Initiation Negative Regulation Of Translation Negative Regulation Of Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Translation Repressor Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Translation Factor Activity, RNA Binding Positive Regulation Of Biosynthetic Process Calcium-dependent Protein Serine/threonine Kinase Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Translation Negative Regulation Of Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Translational Initiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Translation Initiation Factor Activity PML Body Histone H3T6 Kinase Activity Cognition Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Calcium/calmodulin-dependent Protein Kinase Activity Regulation Of Cell Cycle Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Learning Or Memory Translational Initiation
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