MAP3K4 and AXIN1

Number of citations of the paper that reports this interaction (PMID 17726008)
13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MAP3K4	AXIN1
Gene Name		mitogen-activated protein kinase kinase kinase 4	axin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Microtubule Cell Cortex Postsynaptic Density Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	P53 Binding Signal Transducer Activity GTPase Activator Activity Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Enzyme Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity Ubiquitin Protein Ligase Binding Protein Complex Scaffold Identical Protein Binding Protein Homodimerization Activity Protein Self-association SMAD Binding Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Placenta Development Protein Phosphorylation Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade	Protein Polyubiquitination In Utero Embryonic Development Optic Placode Formation Positive Regulation Of Protein Phosphorylation Nucleocytoplasmic Transport Apoptotic Process Activation Of JUN Kinase Activity Determination Of Left/right Symmetry Sensory Perception Of Sound Cell Death Dorsal/ventral Axis Specification Positive Regulation Of Peptidyl-threonine Phosphorylation Forebrain Anterior/posterior Pattern Specification Wnt-activated Signaling Pathway Involved In Forebrain Neuron Fate Commitment Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Olfactory Placode Formation Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Activation Of Protein Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Catenin Import Into Nucleus Post-anal Tail Morphogenesis Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Cellular Protein Complex Assembly Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Embryonic Eye Morphogenesis Axial Mesoderm Formation Negative Regulation Of Protein Metabolic Process Protein Homooligomerization Positive Regulation Of Ubiquitin-protein Transferase Activity Muscle Cell Development Canonical Wnt Signaling Pathway Embryonic Skeletal Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Cellular Response To Organic Cyclic Compound Genetic Imprinting Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways			misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling degradation of AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS		Aging ( 22773346)	Bone mineral density ( 22504420)
Protein-Protein Interactions		26 interactors: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MAPK8 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	43 interactors: AMER1 ANP32A APC BTRC CARM1 CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 GAK GNAS GSK3B JUP LMO2 LRP5 LRP6 MAP3K4 MYC MYOT NCK2 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 RNF111 RUNX2 SENP2 SH3GL1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 UTP14A
Entrez ID		4216	8312
HPRD ID		03886	04819
Ensembl ID		ENSG00000085511	ENSG00000103126
Uniprot IDs		F5H538 J3KNB8 Q9P1M2 Q9Y6R4	O15169
PDB IDs			1DK8 1EMU 1O9U 3ZDI 4B7T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Transferase Activity Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity MAPK Cascade Regulation Of Catalytic Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Signal Transduction By Phosphorylation Apoptotic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Programmed Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway	Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway Regulation Of Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression Canonical Wnt Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Tissue Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Metabolic Process Organ Morphogenesis Anatomical Structure Development System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Developmental Process Organ Development Multicellular Organismal Development Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus
Tagcloud ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deleterious deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe ovarian palb2 pathogenic rare somatic truncation truncations variants	aberrations applying arid2 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Difference) ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe ovarian palb2 pathogenic rare somatic truncation truncations variants	aberrations applying arid2 cdk15 cps1 creating disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Intersection) ?		deleterious