MAP3K4 and TPR

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		MAP3K4	TPR
Gene Name		mitogen-activated protein kinase kinase kinase 4	translocated promoter region, nuclear basket protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoplasmic Dynein Complex Extrinsic Component Of Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket Mitotic Spindle
	Molecular Function	MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Chromatin Binding MRNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Tubulin Binding Heat Shock Protein Binding Protein Homodimerization Activity Protein Anchor Poly(A) RNA Binding Mitogen-activated Protein Kinase Binding Dynein Complex Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Placenta Development Protein Phosphorylation Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Import Into Nucleus Mitotic Cell Cycle Carbohydrate Metabolic Process RNA Import Into Nucleus RNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Nuclear Pore Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic Spindle Assembly Checkpoint Hexose Transport Pathogenesis Gene Expression Regulation Of MRNA Export From Nucleus Regulation Of Glucose Transport Regulation Of Mitotic Sister Chromatid Separation Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Positive Regulation Of Heterochromatin Assembly Regulation Of Protein Stability MRNA Export From Nucleus In Response To Heat Stress Cellular Response To Heat Cellular Response To Interferon-alpha Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Nuclear Matrix Organization Small Molecule Metabolic Process Negative Regulation Of Translational Initiation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Negative Regulation Of RNA Export From Nucleus Nuclear Pore Complex Assembly Cell Division Transmembrane Transport Response To Epidermal Growth Factor Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Mitotic Spindle Assembly
Pathways			Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport
Drugs
Diseases
GWAS		Aging ( 22773346)
Protein-Protein Interactions		26 interactors: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MAPK8 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	11 interactors: APC HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 NUP153 NUP98 SHC1 YWHAQ
Entrez ID		4216	7175
HPRD ID		03886	08927
Ensembl ID		ENSG00000085511	ENSG00000047410
Uniprot IDs		F5H538 J3KNB8 Q9P1M2 Q9Y6R4	P12270
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Transferase Activity Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity MAPK Cascade Regulation Of Catalytic Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Signal Transduction By Phosphorylation Apoptotic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Programmed Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway	Mitotic Cell Cycle Process Nuclear Import Mitotic Cell Cycle Cell Cycle Protein Localization To Nucleus Apoptotic Process Programmed Cell Death Cell Cycle Process Regulation Of Cellular Localization Signal Transduction Cell Death Death Nuclear Pore Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Signaling Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Nuclear Pore Organization Positive Regulation Of Signal Transduction Response To UV-C Pore Complex Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Establishment Of Protein Localization Protein Import Into Nucleus Regulation Of Protein Processing Cellular Response To Stimulus Regulation Of Catalytic Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Transport Activation Of MAPK Activity Response To Radiation Mitotic Cell Cycle Checkpoint Protein Import Cellular Response To Organonitrogen Compound Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Protein Complex Assembly Protein Localization To Organelle Regulation Of Signal Transduction Response To Toxic Substance Mitotic Spindle Assembly Checkpoint Response To Abiotic Stimulus
Tagcloud ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deleterious deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe ovarian palb2 pathogenic rare somatic truncation truncations variants	aa antiproliferative antiviral coexpression comprised curiously dimerization dimers document example exerted highlight hybrid lambda mediator nonfunctional p58ipk perturb pkr repressor select span stranded subdomains tetratricopeptide unrecognized utilizing verified yeast
Tagcloud (Difference) ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deleterious deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe ovarian palb2 pathogenic rare somatic truncation truncations variants	aa antiproliferative antiviral coexpression comprised curiously dimerization dimers document example exerted highlight hybrid lambda mediator nonfunctional p58ipk perturb pkr repressor select span stranded subdomains tetratricopeptide unrecognized utilizing verified yeast
Tagcloud (Intersection) ?