MAP3K4 and DIXDC1

Number of citations of the paper that reports this interaction (PubMedID 15262978)
0

Data Source:
HPRD (in vitro, in vivo)

		MAP3K4	DIXDC1
Description		mitogen-activated protein kinase kinase kinase 4	DIX domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Stress Fiber Cytoplasm Cytosol Cytoskeleton Focal Adhesion Anchoring Junction Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Actin Binding Protein Binding Protein Domain Specific Binding Gamma-tubulin Binding
	Biological Process	MAPK Cascade Placenta Development Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction P38MAPK Cascade Positive Regulation Of JUN Kinase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade	Wnt Signaling Pathway Cerebral Cortex Cell Migration Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Wnt Signaling Pathway Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Differentiation Canonical Wnt Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Aging ( 22773346) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)	Brain morphology (MOSTest) ( 32665545) Smoking initiation ( 33082346) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	8 interacting genes: APP ATXN1 AXIN1 CDC5L MAP3K4 NDEL1 ULK2 ZDHHC17
Entrez ID		4216	85458
HPRD ID		03886	16804
Ensembl ID		ENSG00000085511	ENSG00000150764
Uniprot IDs		F5H538 J3KNB8 Q9P1M2 Q9Y6R4	Q155Q3
PDB IDs			3PZ7
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction MAP Kinase Kinase Activity Regulation Of JNK Cascade Signal Transduction Protein Kinase Activity Intracellular Signaling Cassette Regulation Of Cell Communication Kinase Activity Protein Tyrosine Kinase Activity Cytoplasm Protein Serine/threonine Kinase Activity Apoptotic Process Cellular Senescence Protein Serine Kinase Activity Nucleotide Binding MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Programmed Cell Death Cell Death Positive Regulation Of P38MAPK Cascade Cytosol Cell Surface Receptor Signaling Pathway Thioesterase Binding ATP Binding Regulation Of P38MAPK Cascade Regulation Of Organelle Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Modification Process Developmental Process Cellular Response To Sorbitol JUN Kinase Kinase Activity Regulation Of Cell Cycle Response To Stress Transferase Activity Regulation Of Protein Modification Process Regulation Of ERK1 And ERK2 Cascade Cellular Developmental Process Cytoskeleton Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Axonogenesis Cell Projection Morphogenesis Neuron Projection Morphogenesis Collateral Sprouting Developmental Cell Growth Developmental Growth Involved In Morphogenesis Identical Protein Binding Protein Serine/threonine Kinase Binding Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Amyloid-beta Complex Growth Cone Lamellipodium Response To Light Stimulus Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cytoplasmic Vesicle Signal Transduction Beta-catenin Destruction Complex Assembly Somatic Sensory System Development Perforant Pathway To Dendrate Granule Cell Synapse Developmental Growth Adult Locomotory Behavior Axo-dendritic Transport Acetylcholine Receptor Activator Activity Associative Learning Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Lipoprotein Particle Cell Projection Organization Positive Regulation Of Protein Import Response To Radiation Male Germ-line Sex Determination Axial Mesoderm Formation Neuron Projection Extension Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Neurofilament Cytoskeleton PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Transport Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Intracellular Signal Transduction Memory Developmental Process
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