MAP3K4 and DIXDC1

Number of citations of the paper that reports this interaction (PMID 15262978)
11

Data Source:
HPRD (in vitro, in vivo)

		MAP3K4	DIXDC1
Gene Name		mitogen-activated protein kinase kinase kinase 4	DIX domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Cytosol Focal Adhesion Neuronal Cell Body Protein Complex Axon Terminus
	Molecular Function	MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Actin Binding Protein Binding Protein Domain Specific Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Gamma-tubulin Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Placenta Development Protein Phosphorylation Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade	Cell Cycle Wnt Signaling Pathway Cerebellar Cortex Development Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of Axonogenesis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Aging ( 22773346)
Protein-Protein Interactions		26 interactors: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MAPK8 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	8 interactors: APP ATXN1 AXIN1 CDC5L MAP3K4 NDEL1 ULK2 ZDHHC17
Entrez ID		4216	85458
HPRD ID		03886	16804
Ensembl ID		ENSG00000085511	ENSG00000150764
Uniprot IDs		F5H538 J3KNB8 Q9P1M2 Q9Y6R4	E9PRV4 Q155Q3 Q86SR7
PDB IDs			3PZ7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Transferase Activity Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity MAPK Cascade Regulation Of Catalytic Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Signal Transduction By Phosphorylation Apoptotic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Programmed Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway	Developmental Cell Growth Developmental Growth Involved In Morphogenesis Cell Growth Regulation Of Signal Transduction Developmental Growth Regulation Of Developmental Growth Regulation Of Signaling Axon Cargo Transport Response To Light Stimulus Neuron Projection Extension Visual Learning Visual Behavior Positive Regulation Of JUN Kinase Activity Signaling Neuron Differentiation Cell Communication Forebrain Development Regulation Of JUN Kinase Activity Associative Learning Wnt-activated Signaling Pathway Involved In Forebrain Neuron Fate Commitment Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Response To Radiation Growth Regulation Of Phosphorylation Axonogenesis System Development Regulation Of Neuron Differentiation Adult Locomotory Behavior Synaptic Growth At Neuromuscular Junction Male Germ-line Sex Determination Axon Development RNA Processing Positive Regulation Of JNK Cascade Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Size Microtubule-based Transport Regulation Of Phosphorus Metabolic Process Regulation Of Growth Positive Regulation Of Stress-activated MAPK Cascade Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Learning Intracellular Transport Positive Regulation Of Catalytic Activity Activation Of MAPK Activity Neuron Projection Morphogenesis Collateral Sprouting In Absence Of Injury Primary Sex Determination Axial Mesoderm Formation Generation Of Neurons
Tagcloud ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deleterious deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe ovarian palb2 pathogenic rare somatic truncation truncations variants	angiogenic array catenin gained gsk3beta hey huaier invasiveness ip1 kill knocking lrp6 mobility motility murr ovarian phosphorylations popularity robiniophila rppa s9 scratch skov3 srb trametes untreated viability wnt5a xenografts
Tagcloud (Difference) ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deleterious deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe palb2 pathogenic rare somatic truncation truncations variants	angiogenic array catenin gained gsk3beta hey huaier invasiveness ip1 kill knocking lrp6 mobility motility murr phosphorylations popularity robiniophila rppa s9 scratch skov3 srb trametes untreated viability wnt5a xenografts
Tagcloud (Intersection) ?		ovarian