MAP3K4 and MAP2K6

Number of citations of the paper that reports this interaction (PubMedID 9841871)
44

Data Source:
BioGRID (imaging technique)
HPRD (in vitro, in vivo)

		MAP3K4	MAP2K6
Description		mitogen-activated protein kinase kinase kinase 4	mitogen-activated protein kinase kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Placenta Development Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction P38MAPK Cascade Positive Regulation Of JUN Kinase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade	MAPK Cascade Osteoblast Differentiation Apoptotic Process Signal Transduction Stress-activated Protein Kinase Signaling Cascade Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway P38MAPK Cascade Signal Transduction In Response To DNA Damage Positive Regulation Of MAPK Cascade Stress-activated MAPK Cascade Protein Maturation Regulation Of Cell Cycle Cardiac Muscle Contraction Bone Development Pyroptotic Inflammatory Response Cellular Response To UV-B Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly
Pathways			NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling PKR-mediated signaling
Drugs		Fostamatinib	Fostamatinib Pimasertib
Diseases
GWAS		Aging ( 22773346) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)
Interacting Genes		26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	39 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EIF2AK2 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 NFE2L2 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6
Entrez ID		4216	5608
HPRD ID		03886	03155
Ensembl ID		ENSG00000085511	ENSG00000108984
Uniprot IDs		F5H538 J3KNB8 Q9P1M2 Q9Y6R4	A8K3Y2 P52564
PDB IDs			2Y8O 3ENM 3FME 3VN9 5ETF 8A8M 8P7J 8PM3
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction MAP Kinase Kinase Activity Regulation Of JNK Cascade Signal Transduction Protein Kinase Activity Intracellular Signaling Cassette Regulation Of Cell Communication Kinase Activity Protein Tyrosine Kinase Activity Cytoplasm Protein Serine/threonine Kinase Activity Apoptotic Process Cellular Senescence Protein Serine Kinase Activity Nucleotide Binding MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Programmed Cell Death Cell Death Positive Regulation Of P38MAPK Cascade Cytosol Cell Surface Receptor Signaling Pathway Thioesterase Binding ATP Binding Regulation Of P38MAPK Cascade Regulation Of Organelle Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Modification Process Developmental Process Cellular Response To Sorbitol JUN Kinase Kinase Activity Regulation Of Cell Cycle Response To Stress Transferase Activity Regulation Of Protein Modification Process Regulation Of ERK1 And ERK2 Cascade Cellular Developmental Process Cytoskeleton Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	MAPK Cascade Intracellular Signal Transduction Protein Serine Kinase Activity Protein Kinase Activity Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stress ATP Binding Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Stress-activated MAPK Cascade Nucleotide Binding P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Macromolecule Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Response To Cytokine Protein Phosphorylation Response To Peptide Positive Regulation Of MAPK Cascade Phosphorylation JNK Cascade Immune Response-regulating Signaling Pathway Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAP Kinase Activity Regulation Of Immune System Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Cell Death
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