MAP3K4 and CNTRL

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		MAP3K4	CNTRL
Gene Name		mitogen-activated protein kinase kinase kinase 4	centriolin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Cytoplasm Centrosome Cytosol Membrane
	Molecular Function	MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Placenta Development Protein Phosphorylation Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Cell Division
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Aging ( 22773346)
Protein-Protein Interactions		26 interactors: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MAPK8 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	4 interactors: MAP3K4 MAPK6 TRADD UBC
Entrez ID		4216	11064
HPRD ID		03886	05691
Ensembl ID		ENSG00000085511	ENSG00000119397
Uniprot IDs		F5H538 J3KNB8 Q9P1M2 Q9Y6R4	Q7Z7A1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Transferase Activity Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity MAPK Cascade Regulation Of Catalytic Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Signal Transduction By Phosphorylation Apoptotic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Programmed Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway	MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of MAPK Activity Male Germ-line Sex Determination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Primary Sex Determination Positive Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Protein Processing Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Chorionic Trophoblast Cell Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Chorion Development Apoptotic Signaling Pathway Positive Regulation Of P38MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Hair Follicle Development Viral Protein Processing Phosphorylation Intracellular Signal Transduction Response To UV-C Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Kinase Activity Male Sex Determination Regulation Of P38MAPK Cascade Regulation Of Hair Follicle Development Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Transferase Activity Signaling Cellular Response To Cytokine Stimulus Cell Communication Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Hair Cycle Notch Receptor Processing
Tagcloud ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deleterious deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe ovarian palb2 pathogenic rare somatic truncation truncations variants	ab abi animals bmd colitic colitis dosed dosing elastic experiment extrinsic femoral femur femurs fracture halted investigates mechanical modulus neutralizing noncolitic osteoblast osteoclast prophylactically resorption scl sclerostin ultimate worse
Tagcloud (Difference) ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deleterious deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe ovarian palb2 pathogenic rare somatic truncation truncations variants	ab abi animals bmd colitic colitis dosed dosing elastic experiment extrinsic femoral femur femurs fracture halted investigates mechanical modulus neutralizing noncolitic osteoblast osteoclast prophylactically resorption scl sclerostin ultimate worse
Tagcloud (Intersection) ?