MCM6 and CCNA1

Number of citations of the paper that reports this interaction (PubMedID 15232106)
0

Data Source:
HPRD (in vitro)

		MCM6	CCNA1
Description		minichromosome maintenance complex component 6	cyclin A1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytosol MCM Complex CMG Complex	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication	G1/S Transition Of Mitotic Cell Cycle Male Meiosis I Spermatogenesis Cell Division
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	G0 and Early G1 Telomere Extension By Telomerase Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat percentage and LDL-C (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and LDL-C (pairwise) ( 33619380) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Cocaine dependence ( 31212010) Nickel levels ( 26025379)
Interacting Genes		36 interacting genes: ATRIP CATSPERT CCNA1 CDC42 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 SCNM1 SMC1A SNRPB2 UBE3A ZBTB9	40 interacting genes: ANAPC4 ARID2 BRCA1 BRCA2 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 FZR1 GPS2 H1-1 H1-5 H2BC1 INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 PSMA2 RACK1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC TRIM13 WEE1 XRCC6
Entrez ID		4175	8900
HPRD ID		03485	04946
Ensembl ID		ENSG00000076003	ENSG00000133101
Uniprot IDs		Q14566	A0A140VJG0 P78396
PDB IDs		2KLQ 2LE8 6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process MCM Complex Regulation Of DNA Replication Regulation Of DNA-templated DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Nucleic Acid Metabolic Process Double-strand Break Repair Via Break-induced Replication Nucleoplasm DNA Replication Origin Binding Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Single-stranded DNA Helicase Activity Origin Recognition Complex Chromosome, Telomeric Region CMG Complex Nucleus Mitotic DNA Replication Initiation DNA Repair Chromosome Single-stranded DNA Binding Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Damage Response Double-strand Break Repair Recombinational Repair Regulation Of Nuclear Cell Cycle DNA Replication DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Chromatin Binding Helicase Activity DNA Strand Elongation DNA Recombination Cellular Response To Stress ATP Hydrolysis Activity DNA Replication Preinitiation Complex Assembly Regulation Of Cell Cycle Phase Transition DNA Binding Regulation Of Cell Cycle DNA Helicase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Sister Chromatid Cohesion Positive Regulation Of DNA Replication Regulation Of Cell Cycle Process Nucleotide Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated DNA Replication	Cyclin Binding Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of DNA Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Replication Nucleus Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Catalytic Activity Cell Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Regulation Of Kinase Activity Regulation Of Metabolic Process Chromosome, Telomeric Region Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Phosphorylation Regulation Of Lipid Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle DNA Damage Response Regulation Of Protein Modification Process Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle G2/M Phase Transition Positive Regulation Of DNA Metabolic Process
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