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CCNA1 and RBL2
Number of citations of the paper that reports this interaction (PubMedID
10022926
)
43
Data Source:
HPRD
(in vitro, in vivo)
CCNA1
RBL2
Description
cyclin A1
RB transcriptional corepressor like 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK1 Complex
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Cytosol
Extracellular Exosome
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Protein Binding
Promoter-specific Chromatin Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Cell Division
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Gene Expression
Cell Differentiation
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
G0 and Early G1
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Appendicular lean mass (
33097823
)
Body fat mass (
28552196
)
Fasting insulin (
34059833
)
General cognitive ability (
29844566
)
Height (
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Intelligence (MTAG) (
29326435
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Metabolite levels (
23823483
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
40 interacting genes:
ANAPC4
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
FZR1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
PSMA2
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
TRIM13
WEE1
XRCC6
46 interacting genes:
BRCA1
BRF1
BRF2
BTG3
CCNA1
CCNA2
CCND1
CCND3
CCNE1
CDK2
CDK4
CDK6
CREG1
DCTN1
DGKZ
E2F4
E2F5
EZH2
GRAMD4
HBP1
HDAC1
ID2
KMT5C
LBX1
LDHC
LIN52
MCM7
MNDA
PCBD1
PHB1
PPP1R9B
PPP2CA
RAF1
RBBP8
RBBP9
RINT1
SKP2
SMARCA4
SNW1
SUV39H1
TAF1
TOP1
TP53BP1
UBTF
USP4
XBP1
Entrez ID
8900
5934
HPRD ID
04946
01576
Ensembl ID
ENSG00000133101
ENSG00000103479
Uniprot IDs
A0A140VJG0
P78396
Q08999
PDB IDs
4XI9
5C1D
Enriched GO Terms of Interacting Partners
?
Cyclin Binding
Regulation Of Mitotic Cell Cycle
Nucleoplasm
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle Phase Transition
Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Primary Metabolic Process
Negative Regulation Of Cell Cycle Process
Regulation Of DNA Metabolic Process
Mitotic Cell Cycle Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Replication
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Replication
Nucleus
Cell Cycle G1/S Phase Transition
Signal Transduction In Response To DNA Damage
Regulation Of Catalytic Activity
Cell Division
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Chromosome Organization
Regulation Of Kinase Activity
Regulation Of Metabolic Process
Chromosome, Telomeric Region
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Phosphorylation
Regulation Of Lipid Kinase Activity
Cyclin-dependent Protein Kinase Holoenzyme Complex
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
DNA Damage Response
Regulation Of Protein Modification Process
Cellular Response To Stress
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle G2/M Phase Transition
Positive Regulation Of DNA Metabolic Process
Cell Cycle G1/S Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Nucleoplasm
Regulation Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Nucleus
Cell Cycle Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Regulation Of Primary Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Stress
Negative Regulation Of Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Regulation Of Cell Population Proliferation
Transcription Corepressor Activity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Damage Response
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cyclin A2-CDK2 Complex
Cell Division
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Cycle Phase Transition
Response To Stress
Transcription Regulator Complex
DNA Damage Checkpoint Signaling
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Nucleic Acid Metabolic Process
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Cycle Process
Transcription Preinitiation Complex Assembly
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Tagcloud (Intersection)
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