MCM6 and MCM2

Number of citations of the paper that reports this interaction (PubMedID 12694531)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MCM6	MCM2
Description		minichromosome maintenance complex component 6	minichromosome maintenance complex component 2
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytosol MCM Complex CMG Complex	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Chromosome Nucleolus Cytoplasm Cytosol Cilium MCM Complex CMG Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity	Nucleotide Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding Histone Binding 3'-5' DNA Helicase Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Nucleosome Assembly Apoptotic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Interleukin-4 Cochlea Development Mitotic DNA Replication Initiation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat percentage and LDL-C (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and LDL-C (pairwise) ( 33619380) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		36 interacting genes: ATRIP CATSPERT CCNA1 CDC42 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 SCNM1 SMC1A SNRPB2 UBE3A ZBTB9	57 interacting genes: AKAP8 APP ASF1A ATM ATR ATRIP CCNB2 CCNC CDC6 CDC7 CDK1 CDK2 CDK4 CDK6 CDKN2A CPSF1 CSNK2A1 DBF4 ELL EP300 ESCO2 FBXO7 GNB5 GTF2B GTF2H1 H3-4 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHB1 PHC2 PLK1 PTEN RAD52 RPA1 RPA2 RPA3 RPS4X SIK1 TBP TCEA2 TERF1 TERF2IP UBE3A
Entrez ID		4175	4171
HPRD ID		03485	00303
Ensembl ID		ENSG00000076003	ENSG00000073111
Uniprot IDs		Q14566	P49736
PDB IDs		2KLQ 2LE8 6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	4UUZ 5BNV 5BNX 5BO0 5C3I 5JA4 6XTX 6XTY 6YA7 7CIZ 7CJ0 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 8YJF 8YJM 9CAQ
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process MCM Complex Regulation Of DNA Replication Regulation Of DNA-templated DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Nucleic Acid Metabolic Process Double-strand Break Repair Via Break-induced Replication Nucleoplasm DNA Replication Origin Binding Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Single-stranded DNA Helicase Activity Origin Recognition Complex Chromosome, Telomeric Region CMG Complex Nucleus Mitotic DNA Replication Initiation DNA Repair Chromosome Single-stranded DNA Binding Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Damage Response Double-strand Break Repair Recombinational Repair Regulation Of Nuclear Cell Cycle DNA Replication DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Chromatin Binding Helicase Activity DNA Strand Elongation DNA Recombination Cellular Response To Stress ATP Hydrolysis Activity DNA Replication Preinitiation Complex Assembly Regulation Of Cell Cycle Phase Transition DNA Binding Regulation Of Cell Cycle DNA Helicase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Sister Chromatid Cohesion Positive Regulation Of DNA Replication Regulation Of Cell Cycle Process Nucleotide Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated DNA Replication	DNA Metabolic Process DNA Replication DNA Replication Initiation Nucleic Acid Metabolic Process Nucleoplasm Chromosome, Telomeric Region Regulation Of DNA Replication Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Nucleus DNA Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Recombinational Repair DNA Replication Origin Binding Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombination Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle Phase Transition Protein Localization To Chromosome Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Cellular Response To Stress Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Single-stranded DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Phase Transition Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Chromosome Chromosome Organization Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Protein Localization To Site Of Double-strand Break DNA Damage Checkpoint Signaling Telomere Maintenance Response To Stress Mitotic Cell Cycle Phase Transition
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