MCM6 and CRLS1

Number of citations of the paper that reports this interaction (PubMedID 12771218)
35

Data Source:
HPRD (in vivo)

		MCM6	CRLS1
Description		minichromosome maintenance complex component 6	cardiolipin synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytosol MCM Complex CMG Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Cardiolipin Synthase (CMP-forming) 2-acylglycerol-3-phosphate O-acyltransferase Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication	Lipid Metabolic Process Phospholipid Biosynthetic Process Cardiolipin Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Glycerophospholipid Biosynthetic Process
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Acyl chain remodelling of PG Synthesis of CL
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat percentage and LDL-C (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and LDL-C (pairwise) ( 33619380) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		36 interacting genes: ATRIP CATSPERT CCNA1 CDC42 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 SCNM1 SMC1A SNRPB2 UBE3A ZBTB9	5 interacting genes: F2RL1 FBXO15 MCM6 MCM7 PINK1
Entrez ID		4175	54675
HPRD ID		03485	12187
Ensembl ID		ENSG00000076003	ENSG00000088766
Uniprot IDs		Q14566	Q9UJA2
PDB IDs		2KLQ 2LE8 6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process MCM Complex Regulation Of DNA Replication Regulation Of DNA-templated DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Nucleic Acid Metabolic Process Double-strand Break Repair Via Break-induced Replication Nucleoplasm DNA Replication Origin Binding Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Single-stranded DNA Helicase Activity Origin Recognition Complex Chromosome, Telomeric Region CMG Complex Nucleus Mitotic DNA Replication Initiation DNA Repair Chromosome Single-stranded DNA Binding Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Damage Response Double-strand Break Repair Recombinational Repair Regulation Of Nuclear Cell Cycle DNA Replication DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Chromatin Binding Helicase Activity DNA Strand Elongation DNA Recombination Cellular Response To Stress ATP Hydrolysis Activity DNA Replication Preinitiation Complex Assembly Regulation Of Cell Cycle Phase Transition DNA Binding Regulation Of Cell Cycle DNA Helicase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Sister Chromatid Cohesion Positive Regulation Of DNA Replication Regulation Of Cell Cycle Process Nucleotide Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated DNA Replication	CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Negative Regulation Of JNK Cascade DNA Helicase Activity Proteinase-activated Receptor Activity Regulation Of JNK Cascade Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Protease Binding Positive Regulation Of Renin Secretion Into Blood Stream Helicase Activity Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Recombinational Repair Regulation Of DNA Replication DNA Replication Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Response To Hydrogen Sulfide Positive Regulation Of Cristae Formation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cristae Formation Negative Regulation Of MAPK Cascade Chromosome, Telomeric Region Positive Regulation Of Killing Of Cells Of Another Organism Response To Hydrogen Sulfide Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity C3HC4-type RING Finger Domain Binding Negative Regulation Of Mitochondrial Fission Maintenance Of Protein Location In Mitochondrion Regulation Of Synaptic Vesicle Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neutrophil Mediated Cytotoxicity Double-strand Break Repair Nuclear DNA Replication
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