MCM6 and SCNM1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MCM6	SCNM1
Gene Name		minichromosome maintenance complex component 6	sodium channel modifier 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MCM Complex	Nucleus Nucleolus Nuclear Speck
	Molecular Function	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Identical Protein Binding	Enzyme Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication	MRNA Processing RNA Splicing
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ALS2CR11 CCNA1 CDC45 CDC7 CDKN2A CDT1 CRLS1 DBF4 FAM161A GMNN HDAC1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MLLT3 NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 ZBTB9	43 interactors: AES BLZF1 CCDC33 CCDC85B CDR2 CEP44 GOLGA2 HMG20A IKZF1 INCA1 KRT31 KRT38 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 LZTS2 MCM6 MEOX2 MID2 MIPOL1 MKRN3 NAB2 NOTCH2NL PDE4DIP PLSCR1 PNMA1 PNMA2 PRNP RINT1 RPGRIP1 SPERT SSX2IP SYCE1 TRAF1 TRIM27 TRIM37 TRIM42 TRIM54 UBXN11 ZBTB14 ZDHHC17
Entrez ID		4175	79005
HPRD ID		03485	12162
Ensembl ID		ENSG00000076003	ENSG00000163156
Uniprot IDs		Q14566	Q9BWG6
PDB IDs		2KLQ 2LE8
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle DNA Replication Mitotic Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation Cell Cycle Cell Cycle Process DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change DNA Unwinding Involved In DNA Replication Chromosome Organization Cellular Metabolic Process DNA Conformation Change Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Double-strand Break Repair Cellular Response To Stress Regulation Of Nuclear Cell Cycle DNA Replication DNA Replication Checkpoint Cellular Process Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint DNA Recombination Organelle Organization Negative Regulation Of Cell Cycle	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Viral Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Cell Cycle Negative Regulation Of Interleukin-2 Production Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Viral Transcription Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Release From Host Cell Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Viral Process Positive Regulation Of Neutrophil Differentiation Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Transcription, DNA-templated Cellular Component Assembly RNA Biosynthetic Process Negative Regulation Of Protein Binding Negative Regulation Of Interleukin-2 Secretion Cellular Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of Viral Transcription Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Histone H2A-K119 Monoubiquitination Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Anoikis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Growth Negative Regulation Of Protein Phosphorylation Negative Regulation Of Binding Positive Regulation Of Cell Death Intraciliary Transport Involved In Cilium Morphogenesis
Tagcloud ?		benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Difference) ?		benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Intersection) ?